Intermittent preventive therapy for malaria: arguments in favour of artesunate and sulphamethoxypyrazine - pyrimethamine combination

Malaria Journal

Commentary

Frans Herwig Jansen¹ 

[1] ACT-ion Afrique, Brussels, Belgium;

关键词: Malaria;    Mefloquine;    Artesunate;    Clinical Malaria;    Pyrimethamine;   

DOI  :  10.1186/1475-2875-10-70

 received in 2010-05-21, accepted in 2011-03-29,  发布年份 2011

来源: Springer

【 摘 要 】

Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi.

【 授权许可】

CC BY   
© Jansen; licensee BioMed Central Ltd. 2011