Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis

Reproductive Biology and Endocrinology

Research

Na Zhang¹  Xiaohui Zhang²  Zhenzhen Lu²  Chunhua Zhang²  Mingjiang Li²  Chunrun Yang²  Shasha Qi²  Hui Zhang²  Xingbo Zhao² 

[1] Department of Anesthesiology and Surgery, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, 250021, Jinan, Shandong, People’s Republic of China;Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, 250021, Jinan, Shandong, People’s Republic of China;

关键词: Adenomyosis;    Epithelial Mesenchymal Transition;    Notch1/Numb/Snail Signaling;    Slug;   

DOI  :  10.1186/s12958-015-0084-2

 received in 2015-04-07, accepted in 2015-07-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundEpithelial mesenchymal transition (EMT) is involved in the pathogenesis of adenomyosis, and Notch signaling is crucial to EMT. The objective of this study was to explore Notch1/Numb/Snail signaling in adenomyosis.MethodsThe expression levels of the members of the Notch1/Numb/Snail signaling cascade in normal endometria (proliferative phase: n = 15; secretory phase: n = 15; postmenopausal phase: n = 15) and adenomyotic endometria (proliferative phase: n = 15; secretory phase: n = 15) were determined by immunohistochemistry analysis.ResultsWe found that the expressions of Notch1 and the EMT-related proteins N-cadherin, Snail and Slug were upregulated in the ectopic endometrium of adenomyosis compared with normal endometrium. Numb, a negative regulator of Notch signaling, was significantly decreased in adenomyosis. In addition, reduced immunoexpression of E-cadherin was observed in adenomyosis.ConclusionsWe conclude that Notch1/Numb/Snail signaling plays an important role in the pathogenesis and development of adenomyosis.

【 授权许可】

CC BY   
© Qi et al. 2015