Epigenetics in cancer stem cells

Molecular Cancer

Review

Tan Boon Toh¹  Jhin Jieh Lim¹  Edward Kai-Hua Chow² 

[1] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore;Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore;Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;Centre for Translational Medicine, National University of Singapore, 14 Medical Drive #12-01, 117599, Singapore, Singapore;

关键词: Cancer stem cells;    Epigenetics;    Histone methylation;    Histone methyltransferase;    DNA methylation;    Signaling pathway;   

DOI  :  10.1186/s12943-017-0596-9

 received in 2016-10-05, accepted in 2017-01-19,  发布年份 2017

来源: Springer

【 摘 要 】

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall.

【 授权许可】

CC BY   
© The Author(s). 2017