Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate

BMC Veterinary Research

Research Article

Andréia Vitor Couto do Amaral¹  Ana Paula Araujo Costa²  Rosângela de Oliveira Alves Carvalho²  Luiz Henrique da Silva²  Aline Maria Vasconcelos Lima²  Naida Cristina Borges² 

[1]Department of Veterinary Medicine, School of Veterinary Medicine and Animal Science, Federal University of Goiás, Jataí, GO, Brazil

[2]Department of Veterinary Medicine, School of Veterinary Medicine and Animal Science, Veterinary Hospital, Federal University of Goiás, Caixa Postal 131, Campus Samambaia, CEP 74001-970, Goiânia, Goiás State, Brazil

关键词: Phosphodiesterase type 5 inhibitor;    Color Doppler imaging;    Intraocular pressure;    Mean arterial pressure;    Rabbit;    Eye circulation;   

DOI  :  10.1186/s12917-016-0778-5

 received in 2015-09-02, accepted in 2016-07-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIt has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of the external ophthalmic artery measured prior to treatment and on days one (moment M1), seven (when M2), fourteen (moment M3), twenty-one (moment M4), and thirty (moment M5) of treatment.ResultsThe MAP and OPP values of treated group were lower than those of control group at all times, and the mean values differed statistically at moments M1 (S = 71.52 mmHg, C = 84.76 mmHg, p = 0.0356) and M5 (S = 71.38 mmHg, C = 85.52 mmHg, p = 0.0252). The IOP and color Doppler values of the external ophthalmic artery did not differ between tested groups.ConclusionsThe dose of 10 mg of sildenafil citrate administered to healthy rabbits causes systemic vasodilation and consequently lower values of MAP and OPP. However, it does not induce changes in IOP and retrobulbar hemodynamics identifiable by color Doppler assessment of the external ophthalmic artery.

【 授权许可】

CC BY   
© The Author(s). 2016