The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature

Nutrition Journal

Review

Patricia A Deuster¹  Cynthia V Lentino¹  Rebecca B Costello²  Meredith L Sprengel³  Cindy C Crawford³  Courtney C Boyd³  Meghan L O’Connell³ 

[1] Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814-4799, Bethesda, MD, USA;Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, 20814-4799, Bethesda, MD, USA;Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Room 3B01, MSC 7517, 20892-7517, Bethesda, MD, USA;Samueli Institute, 1737 King Street, Suite 600, 22314, Alexandria, VA, USA;

关键词: Melatonin;    Sleep;    Systematic review;    Rapid evidence assessment of the literature (REAL);    Dietary supplements;    Military health;   

DOI  :  10.1186/1475-2891-13-106

 received in 2014-01-31, accepted in 2014-08-28,  发布年份 2014

来源: Springer

【 摘 要 】

A systematic review was conducted using Samueli Institute’s Rapid Evidence Assessment of the Literature (REAL©) process to determine the evidence base for melatonin as an agent to optimize sleep or improve sleep quality, and generalize the results to a military, civilian, or other healthy, active, adult population. Multiple databases were searched yielding 35 randomized controlled trials (RCTs) meeting the review’s inclusion criteria, which were assessed for methodological quality as well as for melatonin effectiveness. The majority of included studies were high quality (83.0%). Overall, according to Grading Recommendations, Assessment Development and Evaluation (GRADE) methodology, weak recommendations were made for preventing phase shifts from jet lag, for improving insomnia in both healthy volunteers and individuals with a history of insomnia, and for initiating sleep and/or improving sleep efficacy. Based on the literature to date, no recommendations for use in shift workers or to improve hormonal phase shift changes in healthy people can be made at this time. Larger and longer-duration RCTs utilizing well characterized products are needed to warrant melatonin recommendations in young, healthy adults.

【 授权许可】

Unknown   
© Costello et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.