Malaria Journal | |
Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy | |
Review | |
Laurence Slutsker1  Alexis Nzila2  Theonest Mutabingwa3  S Patrick Kachur4  Julie Gutman4  | |
[1] Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Mailstop D-69, 30329-4018, Atlanta, GA, USA;Department of Chemistry, King Fahd University of Petroleum and Minerals, PO Box 468, 31261, Dhahran, Saudi Arabia;Department of Community Medicine, Hubert Kairuki Memorial University, Dar-es-Salaam, Tanzania;Division of Parasitic Diseases & Malaria, Malaria Branch, 1600 Clifton Rd. NE, Mailstop A06, 30329, Atlanta, GA, USA; | |
关键词: Malaria; Sulphadoxine-pyrimethamine; Probenecid; Pregnancy; | |
DOI : 10.1186/1475-2875-11-39 | |
received in 2011-11-02, accepted in 2012-02-09, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
The antifolate sulphadoxine-pyrimethamine (SP) has been used in the intermittent prevention of malaria in pregnancy (IPTp). SP is an ideal choice for IPTp, however, as resistance of Plasmodium falciparum to SP increases, data are accumulating that SP may no longer provide benefit in areas of high-level resistance. Probenecid was initially used as an adjunctive therapy to increase the blood concentration of penicillin; it has since been used to augment concentrations of other drugs, including antifolates. The addition of probenecid has been shown to increase the treatment efficacy of SP against malaria, suggesting that the combination of probenecid plus SP may prolong the useful lifespan of SP as an effective agent for IPTp. Here, the literature on the pharmacokinetics, adverse reactions, interactions and available data on the use of these drugs in pregnancy is reviewed, and the possible utility of an SP-probenecid combination is discussed. This article concludes by calling for further research into this potentially useful combination.
【 授权许可】
CC BY
© Gutman et al; BioMed Central Ltd. 2012
【 预 览 】
Files | Size | Format | View |
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RO202311100303753ZK.pdf | 609KB | download |
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