Assessment of plaque evolution in coronary bifurcations located beyond everolimus eluting scaffolds: serial intravascular ultrasound virtual histology study

Cardiovascular Ultrasound

Research

Christos V Bourantas¹  Bill D Gogas¹  Hector M Garcia-Garcia¹  Il Soo Lee¹  Yoshinobu Onuma¹  Takashi Muramatsu¹  Jung Ho Heo¹  Vasim Farooq¹  Yaojun Zhang¹  Patrick W Serruys¹  Roberto Diletti¹ 

[1] Thoraxcenter, Erasmus Medical Center, ‘s-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands;

关键词: Bifurcation;    Intravascular ultrasound-virtual histology;    Plaque type;    Coronary bifurcation;    Intravascular ultrasound;    Coronary artery disease;    Atherosclerosis;   

DOI  :  10.1186/1476-7120-11-25

 received in 2013-04-23, accepted in 2013-07-18,  发布年份 2013

来源: Springer

【 摘 要 】

PurposeTo evaluate the atherosclerotic evolution in coronary bifurcations located proximally and distally to a bioresorbable scaffold.MethodsThirty bifurcations located >5 mm beyond the scaffolded segment, being investigated with serial intravascular ultrasound virtual histology (IVUS-VH) examinations, at baseline and 2-years, in patients enrolled in the ABSORB cohort B1 study were included in this analysis. In each bifurcation, the frames portraying the proximal rim, in-bifurcation, and distal rim of the ostium of the side branch were analyzed. The geometric parameters and plaque types were evaluated at baseline and 2-years follow-up.ResultsThere were no significant differences in the geometrical parameters such as lumen, vessel and plaque areas as well as in the composition of the atheroma between baseline and 2-years follow-up.When we separately examined the bifurcations located proximally and distally to the scaffolded segment, no changes were found at the distal bifurcations, while at the proximal bifurcations there was a statistical significant decrease in the plaque burden (36.67 ± 13.33% at baseline vs. 35.06 ± 13.20% at 2 years follow-up, p = 0.04).Ten necrotic core rich plaques were found at baseline, of which 2 regressed to either fibrotic plaque or to intimal thickening at 2 years follow-up. The other 8 did not change. Disease progression was noted in 3 plaques (1 adaptive intimal thickening, 1 fibrotic and 1 fibrocalcific plaque) that evolved to necrotic rich plaques.ConclusionsPlaque regression was noted at the bifurcations located proximally to the bioresorbable scaffold but not at these located distally. Additional studies are required to confirm this finding and examine further the effect of drug elution on atherosclerotic evolution.

【 授权许可】

Unknown   
© Lee et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.