Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy: long-term outcomes

World Journal of Surgical Oncology

Research

SongFeng Xu¹  XiuChun Yu¹  Ming Xu¹ 

[1] Orthopedic Department, General Hospital of Jinan Military Commanding Region, No.25# ShiFan Street, 250031, JiNan City, Shandong Prov, China;

关键词: Osteosarcoma;    Chemotherapy;    Adjuvant;    Limb salvage;    Marginal resection;   

DOI  :  10.1186/1477-7819-12-341

 received in 2014-02-07, accepted in 2014-10-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWe report the long-term outcomes of patients with osteosarcoma who underwent effective preoperative chemotherapy and subsequently underwent marginal resection.MethodsWe reviewed the records of 50 patients with osteosarcoma who underwent marginal resection following effective preoperative chemotherapy; 18 were treated with the MMIA (high-dose methotrexate (HD-MTX), adriamycin (ADR), ifosfamide (IFO)) and cisplatin (DDP), and 32 patients were treated with the DIA (DDP, ADR and IFO). protocol. The functions of the affected limb were evaluated using the revised MSTS93 system. The Kaplan-Meier method was used for survival analysis.ResultsAfter a median follow-up of 5.5 years, the rates were: overall 5-year cumulative survival 61.7%, event-free survival 57.7%, recurrence 8.5%, pulmonary metastases 42.6%, and excellent to good function of the affected limb 57.7%.ConclusionsOur results showed that marginal resection can be performed in patients with osteosarcoma who obtain clinically favorable responses to chemotherapy. Patients had a good clinical course and there was no negative effect on rates of survival or local recurrence.

【 授权许可】

Unknown   
© Xu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.