Chronic kidney disease in gout in a managed care setting

BMC Nephrology

Research Article

Mahesh J Fuldeore¹  Victoria Zarotsky²  Aylin A Riedel³  Eswar Krishnan⁴  Omar Dabbous⁵  Bhavik J Pandya⁵ 

[1] Abbott Laboratories, Health Economics & Outcomes Research, Formerly at TAP Pharmaceutical Products Inc., now part of Takeda Pharmaceuticals International Inc, 100 Abbott Park Rd, 60064, North Chicago, IL, USA;OptumInsight, Clinical Services, 22533 Jameson Drive, 91302, Calabasas, CA, USA;OptumInsight, Health Economics & Outcomes Research, 12125 Technology Drive, 55344, Eden Prairie, MN, USA;Stanford University Medical School, Division of Immunology and Rheumatology, 94305, Stanford, CA, USA;Takeda Pharmaceuticals International, Inc., Global Health Economics Outcomes Research, One Takeda Parkway, 60015, Deerfield, IL, USA;

关键词: Chronic Kidney Disease;    Uric Acid;    Gout;    Allopurinol;    Chronic Kidney Disease Patient;   

DOI  :  10.1186/1471-2369-12-36

 received in 2010-09-09, accepted in 2011-08-03,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo study the prevalence of chronic kidney disease (CKD) and its impact on allopurinol dosing and uric acid control among patients with gout.MethodsThis was a retrospective study using data from a large US health plan. Claims and laboratory data were analyzed for enrollees from the health plan database from January 2002 through December 2005. Patients with gout were identified from pharmacy and medical claims data based on the presence of codes for gout medication or gout diagnosis. Severity of CKD was determined using the estimated glomerular filtration rate (eGFR). Allopurinol titration was defined as a change in average daily dose from first prescription to last prescription of ≥ 50 mg.ResultsA total of 3,929 patients were identified for inclusion in this study, 39% of whom had CKD (based on having an eGFR < 90 mL/min/1.73 m2). Subjects with CKD were older (p < 0.01) and more likely to be women (p < 0.01), had a greater number of comorbid conditions (p < 0.01), and were more likely to be prescribed allopurinol (p < 0.01) compared to those with no CKD. The average starting dose of allopurinol was lower among those with CKD, and it decreased with worsening kidney function. Among the 3,122 gout patients who used allopurinol, only 25.6% without CKD and 22.2% with CKD achieved a serum uric acid concentration of < 6.0 mg/dL (p = 0.0409). Also, only 15% of allopurinol users had an upward dose titration (by ≥50 mg), but the average increase in dose did not differ significantly between those with and without CKD.ConclusionsAbout two out of every five patients with gout in this population had CKD. Allopurinol doses were not adjusted in the majority of CKD patients. Serum uric acid control in gout was poor among patients without CKD and even worse among those with CKD.

【 授权许可】

Unknown   
© Fuldeore et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.