Prevalence and risk factors accounting for true silent myocardial ischemia: a pilot case-control study comparing type 2 diabetic with non-diabetic control subjects

Cardiovascular Diabetology

Original Investigation

Cristina Hernández¹  Rafael Simó²  Gemma Francisco³  Andreea Ciudin³  Jaume Candell-Riera⁴  Santiago Aguadé-Bruix⁵ 

[1] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM, Spain;RECAVA (Red de Enfermedades Cardiovasculares), Instituto de Salud Carlos III, Spain;Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM, Spain;RECAVA (Red de Enfermedades Cardiovasculares), Instituto de Salud Carlos III, Spain;Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;Universitat Autònoma de Barcelona, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;RECAVA (Red de Enfermedades Cardiovasculares), Instituto de Salud Carlos III, Spain;Cardiology Department, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;RECAVA (Red de Enfermedades Cardiovasculares), Instituto de Salud Carlos III, Spain;Nuclear Medicine Department, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron 119-129, 08035, Barcelona, Spain;

关键词: Diabetic Patient;    Myocardial Perfusion;    Diabetic Retinopathy;    Perfusion Defect;    Ranibizumab;   

DOI  :  10.1186/1475-2840-10-9

 received in 2010-12-27, accepted in 2011-01-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundGiven the elevated risk of cardiovascular events and the higher prevalence of silent coronary artery disease (CAD) in diabetic versus non-diabetic patients, the need to screen asymptomatic diabetic patients for CAD assumes increasing importante. The aims of the study were to assess prospectively the prevalence and risk factor predictors of true silent myocardial ischemia (myocardial perfusion defects in the absence of both angina and ST-segment depression) in asymptomatic type 2 diabetic patients.MethodsStress myocardial perfusion gated SPECT (Single Photon Emission Computed Tomography) was carried out in 41 type 2 diabetic patients without history of cardiovascular disease (CVD) and 41 nondiabetic patients matched by age and gender.ResultsThere were no significant differences between the two groups regarding either the classic CVD risk factors or left ventricular function. True silent ischemia was detected in 21.9% of diabetic patients but only in 2.4% of controls (p < 0.01). The presence of myocardial perfusion defects was independently associated with male gender and the presence of diabetic retinopathy (DR). The probability of having myocardial perfusion defects in an asymptomatic diabetic patient with DR in comparison with diabetic patients without DR was 11.7 [IC95%: 3.7-37].ConclusionsTrue silent myocardial ischemia is a high prevalent condition in asymptomatic type 2 diabetic patients. Male gender and the presence of DR are the risk factors related to its development.

【 授权许可】

Unknown   
© Hernández et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.