Changes in coagulation markers in children with Mycoplasma pneumoniae pneumonia and their predictive value for Mycoplasma severity

Italian Journal of Pediatrics

Research

Yu-Mei Ma¹  Yong-tao Li¹  Fu-Li Dai¹  Ke Zhi¹  Shu-jun Li²  Ju Zhang²  Meng-zhu Wang² 

[1] Department of Pediatrics, Luoyang Maternal and Child Health Hospital, No. 206 of Tongqu Road, 471000, Luoyang, Henan province, China;Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, No. 88 of Jiankangroad, 453100, Weihui, Henan province, China;

关键词: Coagulation;    Mycoplasma pneumoniae;    Predictive value;    Children;   

DOI  :  10.1186/s13052-023-01545-1

 received in 2023-09-11, accepted in 2023-10-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study investigates the correlation between coagulation levels and the severity of Mycoplasma pneumoniae pneumonia (MPP) in children. In addition, the study analyses the predictive value of coagulation abnormalities in MPP combined with necrotising pneumonia (NP).MethodsA total of 170 children with MPP who underwent treatment between June 2021 and February 2022 were selected for this study. The study population was divided into groups according to the severity of the disease to compare differences in the incidence of coagulation abnormalities between the groups. The participants were also divided into groups according to imaging manifestations to compare the differences in coagulation function among the different groups. All data information was processed for statistical analysis using SPSS Statistics 25.0 and GraphPad Prism 7.0 statistical analysis software.ResultsThe incidence of coagulation abnormalities in the children in the severe MPP (SMPP) group was significantly higher than that in the normal MPP (NMPP) group (P < 0.05). The multi-factor logistic regression analysis revealed that the D-dimer level is an independent risk factor for the development of NP in SMPP (P < 0.05). The receiver operating characteristic curve analysis revealed statistically significant differences (P < 0.05) in D-dimer, fibrinogen degeneration products (FDP), neutrophils, lactate dehydrogenase and serum ferritin for predicting SMPP combined with NP. Bronchoscopic manifestations of coagulation indicators (D-dimer and FDP levels) were significantly higher in the mucus plug group than in the non-mucus plug group, while the activated partial thromboplastin time levels were lower in the former than in the latter (P < 0.05).ConclusionThe degree of elevated D-dimer and FDP levels was positively correlated with the severity of MPP, with elevated serum D-dimer levels (> 3.705 mg/L) serving as an independent predictor of MPP combined with NP in children.

【 授权许可】

CC BY   
© Società Italiana di Pediatria 2023

【 图 表 】

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