Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12–24 month-old infants from Mexico City

Environmental Health

Research

Martha María Téllez-Rojo¹  Brent A. Coull²  Rosalind J. Wright³  Robert O. Wright³  Marcela Tamayo y Ortiz⁴ 

[1] Center for Research in Nutrition and Health, National Institute of Public Health, Universidad No. 655, Col. Santa María Ahuacatitlán, Cerrada los Pinos y Caminera, CP. 62100, Cuernavaca, Morelos, Mexico;Department of Biostatistics, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Building II, Room 413, 02115, Boston, MA, USA;Departments of Pediatrics and Preventive Medicine, Pediatrics Kravis Children’s Hospital, New York, USA;The Mindich Child Health & Development Institute, Icahn School of Medicine at Mount Sinai, Annenberg Building Floor 14th Floor Room 8, 1468 Madison Avenue, 10029, New York City, NY, USA;Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 17 East 102 Street Floor 3 West Room D3-110, 10029, New York City, NY, USA;National Council of Science and Technology, Center for Nutrition Research and Health, National Institute of Public Health, 7a. Cerrada de Fray Pedro de Gante # 50, Col. Sección XVI Tlalpan, C.P. 14080, México D.F., Mexico;Center for Research in Nutrition and Health, National Institute of Public Health, Universidad No. 655, Col. Santa María Ahuacatitlán, Cerrada los Pinos y Caminera, CP. 62100, Cuernavaca, Morelos, Mexico;

关键词: Lead;    Cortisol;    Epidemiology;    Prenatal;   

DOI  :  10.1186/s12940-016-0124-1

 received in 2015-09-10, accepted in 2016-02-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCortisol has functions on homeostasis, growth, neurodevelopment, immune function and the stress response. Secretion follows a diurnal rhythm that mediates these processes. Our objective was to examine the association between prenatal lead exposure and infant diurnal cortisol rhythms.MethodsWe measured infant cortisol rhythms in saliva collected repeatedly over 2 days at either 12 (n = 255) or 18–24 (n = 150) months of age. Prenatal lead exposure was assessed by measuring maternal pregnancy blood lead levels and early postnatal maternal bone lead content. We analyzed age-specific basal secretion and the association between trimester-specific and cumulative lead exposure with a) change in total diurnal cortisol and b) the shape of the cortisol curve across the length of the day.ResultsOur results showed age related differences in salivary cortisol secretion and an age dependent association with maternal lead exposure. In age-stratified models we saw an inverse association between lead and cortisol levels in 12-month-old infants and a positive association for 18–24-month-old infants. For the 12-month-old infants 2nd-trimester-lead ≥10 μg/dL was associated with 40 % lower cortisol levels (95 % CI (−57, −16)) and a significant change in the shape of the cortisol curve (p = 0.01), compared to infants with low blood lead levels (<5 μg/dL).ConclusionsBasal cortisol secretion changes with age. Increased early gestation lead exposure alters diurnal cortisol rhythms and the association is modified by infant age, perhaps representing an early maturation of cortisol homeostasis.

【 授权许可】

CC BY   
© Tamayo y Ortiz et al. 2016