Single breath-hold 3D measurement of left atrial volume using compressed sensing cardiovascular magnetic resonance and a non-model-based reconstruction approach

Journal of Cardiovascular Magnetic Resonance

Technical Notes

Amit Bermano¹  Matthias Stuber²  Pierre Monney³  Juerg Schwitter³  Amir Vaxman⁴  Craig Gotsman⁵  Nikolaos Stergiopulos⁶  Orestis Vardoulis⁶  Janine Schwitter⁷ 

[1] Computer Graphics lab, ETH Zurich & Disney Research Zurich, Zurich, Switzerland;Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland;Center for Biomedical Imaging, Lausanne, Switzerland;Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne, Switzerland;Geometric Modeling and Industrial Geometry group, Vienna University of Technology, Vienna, Austria;Jacobs Technion-Cornell Institute at Cornell Tech, New York, USA;Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, Swiss Federal Institute of Technology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;University of Fribourg, Biomedical Sciences, Fribourg, Switzerland;

关键词: Cardiovascular Magnetic Resonance;    Left Atrial;    Left Atrial Volume;    Reference Volume;    Left Atrial Function;   

DOI  :  10.1186/s12968-015-0147-8

 received in 2014-11-18, accepted in 2015-05-11,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundLeft atrial (LA) dilatation is associated with a large variety of cardiac diseases. Current cardiovascular magnetic resonance (CMR) strategies to measure LA volumes are based on multi-breath-hold multi-slice acquisitions, which are time-consuming and susceptible to misregistration.AimTo develop a time-efficient single breath-hold 3D CMR acquisition and reconstruction method to precisely measure LA volumes and function.MethodsA highly accelerated compressed-sensing multi-slice cine sequence (CS-cineCMR) was combined with a non-model-based 3D reconstruction method to measure LA volumes with high temporal and spatial resolution during a single breath-hold. This approach was validated in LA phantoms of different shapes and applied in 3 patients. In addition, the influence of slice orientations on accuracy was evaluated in the LA phantoms for the new approach in comparison with a conventional model-based biplane area-length reconstruction. As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR-CMR) was acquired during mid-diastole to yield accurate LA volumes.ResultsPhantom studies. LA volumes were accurately measured by CS-cineCMR with a mean difference of −4.73 ± 1.75 ml (−8.67 ± 3.54 %, r2 = 0.94). For the new method the calculated volumes were not significantly different when different orientations of the CS-cineCMR slices were applied to cover the LA phantoms. Long-axis “aligned” vs “not aligned” with the phantom long-axis yielded similar differences vs the reference volume (−4.87 ± 1.73 ml vs −4.45 ± 1.97 ml, p = 0.67) and short-axis “perpendicular” vs “not-perpendicular” with the LA long-axis (−4.72 ± 1.66 ml vs −4.75 ± 2.13 ml; p = 0.98). The conventional bi-plane area-length method was susceptible for slice orientations (p = 0.0085 for the interaction of “slice orientation” and “reconstruction technique”, 2-way ANOVA for repeated measures). To use the 3D-HR-CMR as the reference for LA volumes in patients, it was validated in the LA phantoms (mean difference: −1.37 ± 1.35 ml, −2.38 ± 2.44 %, r2 = 0.97). Patient study: The CS-cineCMR LA volumes of the mid-diastolic frame matched closely with the reference LA volume (measured by 3D-HR-CMR) with a difference of −2.66 ± 6.5 ml (3.0 % underestimation; true LA volumes: 63 ml, 62 ml, and 395 ml). Finally, a high intra- and inter-observer agreement for maximal and minimal LA volume measurement is also shown.ConclusionsThe proposed method combines a highly accelerated single-breathhold compressed-sensing multi-slice CMR technique with a non-model-based 3D reconstruction to accurately and reproducibly measure LA volumes and function.

【 授权许可】

CC BY   
© Vardoulis et al. 2015