The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study

Journal of Cardiovascular Magnetic Resonance

Research

Jinnan Wang¹  Mary McGrae McDermott²  Timothy J Carroll³  Debiao Li³  Zhaoyang Fan³  Feiyu Li⁴  Baocheng Chu⁵  Daniel S Hippe⁵  Xihai Zhao⁵  Chun Yuan⁵  Thomas S Hatsukami⁶  Christopher M Kramer⁷ 

[1] Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, NY, USA;Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Il, USA;Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Il, USA;Department of Radiology, Peking University First Hospital, Beijing, China;Department of Radiology, University of Washington, Seattle, WA, USA;Department of Radiology, University of Washington, Seattle, WA, USA;Department of Surgery, University of Washington, Seattle, WA, USA;Departments of Radiology and Medicine, University of Virginia, Charlottesville, VA, USA;

关键词: Cardiovascular Magnetic Resonance;    Peripheral Arterial Disease;    Superficial Femoral Artery;    Lumen Area;    Wall Area;   

DOI  :  10.1186/1532-429X-12-37

 received in 2010-01-21, accepted in 2010-07-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAtherosclerotic plaque morphology and components are predictors of subsequent cardiovascular events. However, associations of plaque eccentricity with plaque morphology and plaque composition are unclear. This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR).MethodsTwenty-eight subjects with an ankle-brachial index less than 1.00 were examined with 1.5T high-spatial-resolution, multi-contrast weighted CMR. One hundred and eighty diseased locations of the proximal superficial femoral artery (about 40 mm) were analyzed. The eccentric lesion was defined as [(Maximum wall thickness- Minimum wall thickness)/Maximum wall thickness] ≥ 0.5. The arterial morphology and plaque components were measured using semi-automatic image analysis software.ResultsOne hundred and fifteen locations were identified as eccentric lesions and sixty-five as concentric lesions. The eccentric lesions had larger wall but similar lumen areas, larger mean and maximum wall thicknesses, and more calcification and lipid rich necrotic core, compared to concentric lesions. For lesions with the same lumen area, the degree of eccentricity was associated with an increased wall area. Eccentricity (dichotomous as eccentric or concentric) was independently correlated with the prevalence of calcification (odds ratio 3.78, 95% CI 1.47-9.70) after adjustment for atherosclerotic risk factors and wall area.ConclusionsPlaque eccentricity is associated with preserved lumen size and advanced plaque features such as larger plaque burden, more lipid content, and increased calcification in the superficial femoral artery.

【 授权许可】

Unknown   
© Li et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.