CD44/CD24 Expression in recurrent gastric cancer: a retrospective analysis

BMC Gastroenterology

Research Article

Chung-Wei Lee¹  Chin-Cheng Lee²  Chih-Ming Ou Yang³  Yenn-Hwei Chou³  Chao-Sheng Liao³  Ching-Shya Yong³ 

[1]Department of Biological Engineering, Massachusetts Institute of Technology, Massachusetts, USA

[2]Department of Pathology, Shin Kong Wu Ho-Su Memorial Hospital, No.95, Wen Chang RoadShih Lin District, Taipei City, 11120, Taiwan

[3]Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, No.95, Wen Chang Road, 11120, Shih Lin District, Taipei City, Taiwan

关键词: CD44;    CD24;    Prognosis;    Recurrent gastric cancer;   

DOI  :  10.1186/1471-230X-12-95

 received in 2012-03-27, accepted in 2012-07-17,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo correlate CD44/CD24 expression with gastric cancer recurrence and prognosis. Gastric cancer is the second leading cause of cancer mortality due to the high recurrence rate, of which the molecular signature has not yet been identified.MethodsWe retrospectively reviewed the hospital records of patients with gastric cancer. Among 500 patients receiving curative resection, 95 patients had recurrence. Twenty patients from the recurrence group (95 patients) and 20 patients from the non-recurrence group (405 patients) were randomly selected and identified as “study” and “control” groups, respectively. We reviewed patients’ histological study of CD44/CD24 expression by performing immunohistochemistry and recurrence rate.ResultsStudy group had higher TNM stage (III-IV) than control group (80% vs. 25%, P = 0.001). Proportion of lymph node metastasis was significantly higher in study group than that in control group (90% vs. 45%, P = 0.002), and proportion of patients with 5 or more metastatic lymph nodes was also significantly higher in study group than in control group (45% vs. 15%, P = 0.007). Univariate analysis revealed no difference in risk of gastric cancer recurrence between CD44+ and CD44- patients (OR = 1.00, 95% CI: 0.29-3.45, P =1.000). CD24+ patients showed no greater significance of gastric cancer recurrence than CD24- patients (OR = 1.86, 95% CI: 0.52-6.61, P = 0.339). After adjusting for other risk factors, the association of CD44 expression (aOR = 0.66, 95% CI: 0.10-4.26, P = 0.658), CD24 expression (aOR = 0.09, 95% CI: 0.01-1.35, P = 0.081) or combined (CD44/CD24) with gastric cancer recurrence were not significant.ConclusionNeither individual expression of CD24 or CD44, nor combined expression of CD44/CD24 was associated with recurrence of gastric carcinoma.

【 授权许可】

Unknown   
© Yong et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.