Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

Cardiovascular Ultrasound

Research

Daniel G Blanchard¹  Thomas J Waltman¹  Andrew M Kahn¹  Jason P Brown²  Nicholas Olson²  Michael M Madani³  William R Auger⁴ 

[1] Division of Cardiology, UCSD Sulpizio Family Cardiovascular Center, 9350 Campus Point Drive, 92037, La Jolla, CA, USA;Division of Cardiology, University of California San Diego Medical Center, 200 W. Arbor Drive, 92103, San Diego, CA, USA;Division of Cardiothoracic Surgery, UCSD Sulpizio Family Cardiovascular Center, 9350 Campus Point Drive, 92037, La Jolla, CA, USA;Division of Pulmonary Medicine, UCSD Sulpizio Family Cardiovascular Center, 9350 Campus Point Drive, 92037, La Jolla, CA, USA;

关键词: Right Ventricle;    Pulmonary Vascular Resistance;    Circumferential Strain;    Radial Strain;    Speckle Tracking;   

DOI  :  10.1186/1476-7120-8-43

 received in 2010-08-09, accepted in 2010-09-27,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundEchocardiographic evaluation of left ventricular (LV) strain and strain rate (SR) by 2D speckle tracking may be useful tools to assess chronic thromboembolic pulmonary hypertension (CTEPH) severity as well as response to successful pulmonary thromboendarterectomy (PTE).MethodsWe evaluated 30 patients with CTEPH before and after PTE using 2D speckle tracking measurements of LV radial and circumferential strain and SR in the short axis, and correlated the data with right heart catheterization (RHC).ResultsPTE resulted in a decrease in mean PA pressure (44 ± 15 to 29 ± 9 mmHg), decrease in PVR (950 ± 550 to 31 ± 160 [dyne-sec]/cm5), and an increase in cardiac output (3.9 ± 1.0 to 5.0 ± 1.0 L/min, p < 0.001 for all). Circumferential and posterior wall radial strain changed by -11% and +15% respectively (p < 0.001 for both). Circumferential SR and posterior wall radial SR changed by -7% and 6% after PTE. While the increase in posterior wall SR with PTE reached statistical significance (p = 0.04) circumferential SR did not (p = 0.07). In addition, septal radial strain and SR did not change significantly after PTE (p = 0.1 and 0.8 respectively). Linear regression analyses of circumferential and posterior wall radial strain and SR revealed little correlation between strain/SR measurements and PVR, mean PA pressure, or cardiac output. However, change in circumferential strain and change in posterior wall radial strain correlated moderately well with changes in PVR, mean PA pressure and cardiac output (r = 0.69, 0.76, and 0.51 for circumferential strain [p < 0.001 for all] and r = 0.7, 0.7, 0.45 for posterior wall radial strain [p = 0.001, 0.001, and 0.02, respectively]).ConclusionsLV circumferential and posterior wall radial strain change after relief of pulmonary arterial obstruction in patients with CTEPH, and these improvements occur rapidly. These changes in LV strain may reflect effects from improved LV diastolic filling, and may be useful non-invasive markers of successful PTE.

【 授权许可】

Unknown   
© Olson et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.