A case report: delayed high fever and maculopapules during Sorafenib treatment of ectopic hepatocellular carcinoma

BMC Cancer

Case Report

Jianguo Sun¹  Tianxiang Cui¹  Shaojiang Huang¹  Xinwei Diao²  Xiewan Chen³ 

[1] Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, China;Department of pathology, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, China;Medical English Department, College of Basic Medicine, Third Military Medical University, 400038, Chongqing, China;

关键词: Sorafenib;    Delayed reaction;    High fever;    Maculopapules;    Ectopic hepatocellular carcinoma;   

DOI  :  10.1186/s12885-016-2590-9

 received in 2016-01-27, accepted in 2016-07-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSorafenib is the standard first-line therapy for hepatocellular carcinoma (HCC) and probably ectopic hepatocellular carcinoma (EHCC) as well. No report involves a side effect of delayed high fever of sorafenib. This manuscript describes a case of EHCC in the thoracic and abdominal cavities, who showed a delayed high fever and maculopapules during sorafenib treatment.Case presentationThe patient is a 63-year-old Chinese male with advanced EHCC, taking sorafenib 400 mg twice daily. On the tenth day, red maculopapules appeared all over the body. On the same day, the patient began to suffer from continuous high fever. Due to these effects, the patient was asked to cease sorafenib treatment, and the high fever and maculopapules were alleviated quickly. However, the symptoms were present again upon re-challenge of sorafenib. Prednisone was then administered to control the symptoms, with the dosage gradually reduced from 30 to 5 mg/day in 1.5 months. No recurrence of fever or maculopapules has been found. Tumor response reached partial response (PR) and progression free survival (PFS) reached 392 days + by the date of Apr. 14th, 2016.ConclusionEHCC could be treated like orthotopic HCC by oral administration of sorafenib, which shows good tumor response and survival benefit. Delayed high fever and maculopapules are potential, rare and severe side effects of sorafenib, and could be effectively controlled by glucocorticoid.

【 授权许可】

CC BY   
© The Author(s). 2016