Vascular structure and function and their relationship with health-related quality of life in the MARK study

BMC Cardiovascular Disorders

Research Article

José I. Recio-Rodríguez¹  Jose A. Maderuelo-Fernandez¹  Cristina Agudo-Conde¹  Sara Mora-Simón²  Luis García-Ortiz³  Emiliano Rodriguez-Sanchez⁴  Manuel A. Gómez-Marcos⁴  Ruth Martí⁵  Rafel Ramos-Blanes⁶  John Guillaumet⁷ 

[1] Primary Care Research Unit, The Alamedilla Health Center. Castilla and León Health Service (SACyL), Biomedical Research Institute of Salamanca (IBSAL), 37003, Salamanca, Spain;Primary Care Research Unit, The Alamedilla Health Center. Castilla and León Health Service (SACyL), Biomedical Research Institute of Salamanca (IBSAL), 37003, Salamanca, Spain;Basic Psychology, Psychobiology and Behavioral Sciences Methodology Department, University of Salamanca, Salamanca, Spain;Primary Care Research Unit, The Alamedilla Health Center. Castilla and León Health Service (SACyL), Biomedical Research Institute of Salamanca (IBSAL), 37003, Salamanca, Spain;Biomedical and Diagnostic Sciences Department, University of Salamanca, Salamanca, Spain;Primary Care Research Unit, The Alamedilla Health Center. Castilla and León Health Service (SACyL), Biomedical Research Institute of Salamanca (IBSAL), 37003, Salamanca, Spain;Department of Medicine, University of Salamanca, Salamanca, Spain;Research Unit Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain;Girona Biomedical Research Institute (IDIBGI), Dr. Trueta University Hospital, Girona, Spain;Research Unit Family Medicine, Girona. Jordi Gol Institute for Primary Care Research (IDIAP Jordi Gol), Catalonia, Spain;Translab Research Group. Medical Sciences Department, School of Medicine, University of Girona, Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Dr. Trueta University Hospital, Girona, Spain;San Agustín Health Center, Illes Balears Health Service (IBSALUT), Palma de Mallorca, Spain;

关键词: Health-related quality of life;    Arterial stiffness;    Ankle-brachial index;    Brachial ankle pulse wave velocity;    Cardio-ankle vascular index;    Augmentation index;   

DOI  :  10.1186/s12872-016-0272-9

 received in 2016-01-16, accepted in 2016-05-04,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThere is limited evidence concerning the relationship between vascular disease and health-related quality of life (HRQL). We investigated the relationship between vascular structure and function with health-related quality of life in a population with intermediate cardiovascular risk.MethodsThis study analyzed 303 subjects with ankle-brachial index (ABI) values ranging from 0.9 to 1.4 who were included in the MARK study (age 35 to 74 years; mean:60.5 ± 8.5), of which 50.2 % were women. Measurements included: ABI, brachial-ankle pulse wave velocity (ba-PWV), and cardio-ankle vascular index (CAVI), all measured using the VaSera device. The central augmentation index was adjusted to 75 lpm (AIx_75) using the Mobil-O-Graph device. HRQL was assessed by the Spanish version of the SF-12, version2. The highest obtained CAVI and ba-PWV values and the lowest ABI values were considered for the study.ResultsThe cohort was composed of21 % smokers, 76 % hypertensive patients, and 24 % diabetic patients. The ABI mean was 1.09 ± 0.07,the ba-PWV mean was 14.64 ± 2.55 m/s with a 12.9 % of subjects higher than 17.5 m/s, AIx_75 26.46 ± 14.05, and CAVI 8.61 ± 1.08 with a 36.6 % of subjects higher than 9. Men scored higher than women in the HRQL measurements for physical (PSC-12; 49.9 vs. 46.9, p = 0.004) and mental (MSC-12) domains (51.2 vs. 47.7, p = 0.003). Age was positively correlated with CAVI (r = 0.547), ba-PWV (r = 0.469), AIx_75 (r = 0.255, p < 0.01), and the MSC-12 (r = 0.147, p < 0.05), but not the PSC-12. In the adjusted multiple linear regression analysis, the positive association of ABI and CAVI with the PSC-12 was maintained.ConclusionsThe ABI in the normal range has a positive association with the PSC-12 of HRQL evaluated with the SF-12. The CAVI also showed a positive association with the PSC-12 of HRQL.Trial RegistrationClinicalTrials.gov Identifier: NCT01428934.

【 授权许可】

CC BY   
© García-Ortiz et al. 2016