Effects of Tongmai oral liquid in femoral ateriovenous fistula

BMC Complementary and Alternative Medicine

Research Article

Wei Mao¹  Kun Bao¹  Ni-Zhi Yang¹  Yi-Qun Lin¹  Xi-Na Jie¹  Wen-Jia Geng¹  Guan-Su Wang¹  Pei-Ling Su²  Han-Guo Peng³ 

[1] Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), No.111 of Dade Road, 510120, Guangzhou, China;Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), No.111 of Dade Road, 510120, Guangzhou, China;Department of Nephrology, The Third Affiliated Hospital, Guangxi University of Chinese Medicine (Liuzhou traditional Chinese Medical Hospital), No.32 of Jiefang Road, 545001, Liuzhou, China;Department of Nephrology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), No.111 of Dade Road, 510120, Guangzhou, China;Jiangmen Xinhui District Hospital of Chinese Medicine, No.47 of Huimin Road, 529100, Jiangmen, China;

关键词: Tongmai oral liquid;    Early fistula maturation;    Hemodialysis;   

DOI  :  10.1186/s12906-015-0844-8

 received in 2015-01-18, accepted in 2015-09-02,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThis study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation.MethodsFifteen female and fifteen male SPF New Zealand rabbits were randomly allocated into 3 groups including control, Aspirin and Tongmai oral liquid groups. A side-to-side femoral arteriovenous fistula was established in each rabbit and then animals were treated with Aspirin or Tongmai oral liquid for 2 weeks. The concentrations of circulating ET-1 and NO were determined before and after operation (on preoperative day, operative day, post-D1, post-D3, post-D7 and post-D15), respectively. Blood flow of the fistula stoma and contralateral artery and vein was determined on the 15th postoperative day. Last, the fistula stoma was dissected to observe patency, thrombosis and adhesion with surrounding tissues.Results28 rabbits survived during the surgical process and the following 15-day observational period. Tissue adhesion of arteriovenous fistula with surrounding tissues was improved and fistula thrombosis was reduced by treatment with Tongmai oral liquid. NO concentration decreased to a different extent after vascular surgery. Tongmai oral liquid failed to regulate the equilibrium between NO and ET-1, but it improved blood flow of fistula stoma, as compared to control and Aspirin groups. Blood flow of fistula stoma in the three groups was lower than that of the contralateral femoral artery.ConclusionsTongmai oral liquid improved the function of femoral ateriovenous fistula in the rabbit model by increasing blood flow and reducing thrombosis, probably not by regulating the dynamic equilibrium between NO and ET-1.

【 授权许可】

CC BY   
© Su et al. 2015

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