Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease

BMC Pulmonary Medicine

Research Article

Shunsuke Uno¹  Hiroshi Fujiwara¹  Naoki Hasegawa¹  Yoshifumi Uwamino²  Satoshi Okamori³  Makoto Ishii³  Kazuma Yagi³  Hirofumi Kamata³  Tomoko Betsuyaku³  Ho Namkoong³  Yohei Funatsu³  Shoji Suzuki⁴  Takanori Asakura⁴  Tomoyasu Nishimura⁵ 

[1] Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, 160-8582, Tokyo, Japan;Department of Laboratory Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan;Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan;Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan;Japan Society for the Promotion of Science, Chiyoda, Tokyo, Japan;Health Center, Keio University, Shinjuku, Tokyo, Japan;

关键词: Colonisation;    Noncystic fibrosis bronchiectasis (NCFBE);    Health-related quality of life (HRQL);    Mycobacterium avium;    Nontuberculous mycobacteria (NTM);    Pseudomonas aeruginosa;    St. George’s Respiratory Questionnaire (SGRQ);    36-item short-form health survey (SF-36);   

DOI  :  10.1186/s12890-017-0544-x

 received in 2017-08-03, accepted in 2017-11-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIn bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients.MethodsThis cross-sectional study was conducted using the Registry of Prospective Cohort Study including MACLD patients. The 36-item Short-Form health survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ) were administered to assess clinical outcomes. Clinical variables included treatment and sputum culture status, pulmonary function tests, cavitary lesions, and modified Reiff scores on high-resolution computed tomography.ResultsThe study included 244 MACLD patients (median age, 68 years; 196 women), 19 of whom had chronic PA infection. Modified Reiff score was higher in patients with chronic infection than in those without (P = 0.028). Regarding SF-36 scores, physical functioning subscale scores were significantly lower in patients with chronic infection (P = 0.029). Additionally, SGRQ symptoms, impact, and total scores were significantly higher in patients with chronic infection. During analysis of covariance comparisons, SGRQ symptoms and impact scores were significantly higher for patients with chronic infection (P = 0.043 and 0.021, respectively).ConclusionsMACLD patients with chronic PA infection exhibited significantly higher SGRQ scores, indicating impaired HRQL. Chronic PA infection was significantly associated with the severity of bronchiectasis.

【 授权许可】

CC BY   
© The Author(s). 2017