The influence of cardiovascular morbidity on the prognosis in prostate cancer. Experience from a 12-year nationwide Danish population-based cohort study

BMC Cancer

Research Article

Mette Søgaard¹  Mette Nørgaard¹  Michael Borre²  Truls E Bjerklund Johansen²  Christina G Jespersen³ 

[1] Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, 8200, Aarhus N, Denmark;Department of Urology, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200, Aarhus N, Denmark;Department of Urology, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200, Aarhus N, Denmark;Institute of Clinical Medicine, Aarhus University Hospital, Brendstrupgaardsvej 100, 8200, Aarhus N, Denmark;

关键词: Prostate Cancer;    Ischemic Heart Disease;    Prostate Cancer Patient;    Charlson Comorbidity Index;    Prostate Cancer Diagnosis;   

DOI  :  10.1186/1471-2407-11-519

 received in 2011-07-06, accepted in 2011-12-15,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo determine the impact of preexisting ischemic heart disease (IHD) and stroke on overall survival in prostate cancer patients.MethodsWe conducted a cohort study of patients with incident prostate cancer registered in the Danish Cancer Registry from 1997 through 2008. We identified patients diagnosed with IHD or stroke prior to the date of prostate cancer diagnosis in the Danish National Patient Registry. We constructed Kaplan-Meier curves to analyze time to death and Cox regression was used to estimate hazard ratios (HRs) to compare mortality rates by preexisting IHD or stroke status, adjusting for age, stage, comorbidity, and calendar period.ResultsOf 30,721 prostate cancer patients, 4,276 (14%) had preexisting IHD and 1,331 (4%) preexisting stroke. Crude 1- and 5-year survival rates were 85% and 44% in men without preexisting IHD or stroke, 81% and 36% in men with preexisting IHD, and 78% and 27% in men with preexisting stroke. Adjusted HRs were 1.05 (95% CI 1.00-1.10) for patients with IHD and 1.20 (95% CI 1.12-1.30) for patients with stroke compared with patients without preexisting IHD or stroke.ConclusionsPreexisting IHD had minimal impact on mortality in prostate cancer patients, whereas overall mortality was 20% higher in prostate cancer patients with preexisting stroke compared to those without IHD or stroke. These results highlight the importance of differentiating between various comorbidities.

【 授权许可】

CC BY   
© Jespersen et al; licensee BioMed Central Ltd. 2011