White cell count and platelet count associate with histological alcoholic hepatitis in jaundiced harmful drinkers

BMC Gastroenterology

Research Article

Alastair D Burt¹  Christopher P Day¹  Christopher Wells²  Mark Hudson²  Steven Masson²  Stuart Kendrick²  Timothy Hardy³  Stephen F Stewart⁴ 

[1] Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK;The Liver Unit, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK;The Liver Unit, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK;Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK;The Liver Unit, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK;The Centre for Liver Disease, Mater Misericordiae University Hospital, 55 Eccles Street, Dublin 7, Irish Republic;

关键词: Alcoholic hepatitis;    Diagnosis;    Accuracy;    Biopsy;    Biochemical markers;   

DOI  :  10.1186/1471-230X-13-55

 received in 2012-08-15, accepted in 2013-03-15,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPatients with suspected alcoholic hepatitis and a Discriminant Function ≥32 underwent liver biopsy to confirm the diagnosis. Of these (n = 58), 43 had histological features of alcoholic hepatitis and 15 (25%) did not.We aimed to determine the laboratory features that differentiated those patients with a histological diagnosis of alcoholic hepatitis from those without, and assess potential clinical utility.MethodsLaboratory investigations at presentation for each of the histologically confirmed cases of alcoholic hepatitis (n = 43) were compared to those without (n = 15) to determine whether there were differences between the two groups. Univariate analysis was by Mann Whitney U Test and Multivariate analysis was by a stepwise approach.ResultsWhite cell count (16.2 ± 10.5 v 6.9 ± 3.5 (× 109/L); p = 0.0001) and platelet count (178 ± 81 v 98.4 ± 43 (× 109/L); p = 0.0005) were higher in the patients with histological features of alcoholic hepatitis than in those without. The area under the ROC curve for AH diagnosis was estimated to be 0.83 (0.73, 0.94) and 0.81 (0.69, 0.93) for white cell count and platelet count respectively.ConclusionsClinicians cannot accurately differentiate patients with or without alcoholic hepatitis without liver biopsy. This is critically important when deciding on specific therapies such as corticosteroids or when interpreting data from future trials in which biopsy is not mandated. In situations where liver biopsy is unsuitable or unavailable the white cell and platelet counts can be used to determine the likelihood of histological alcoholic hepatitis and guide treatment.

【 授权许可】

Unknown   
© Hardy et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.