Coronary artery calcium findings in asymptomatic subjects with family history of premature coronary artery disease

BMC Cardiovascular Disorders

Research Article

Catalin Taraboanta¹  Jiri Frohlich¹  Bruce B Forster²  Cameron J Hague²  GB John Mancini³ 

[1] Department of Pathology and Laboratory medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;Healthy Heart Prevention Clinic, Providence Heart and Lung Institute, St. Paul Hospital, Vancouver, BC, Canada;Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;Healthy Heart Prevention Clinic, Providence Heart and Lung Institute, St. Paul Hospital, Vancouver, BC, Canada;Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada;

关键词: Coronary Artery Calcification;    Coronary Artery Calcification Score;    Framingham Risk Score;    Subclinical Atherosclerosis;    Agatston Score;   

DOI  :  10.1186/1471-2261-12-53

 received in 2012-02-15, accepted in 2012-06-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo evaluate the frequency of positive coronary arteries calcium (CAC) scores in a unique population of asymptomatic first degree relatives (FDRs) of patients with angiographically confirmed early onset of coronary artery disease (CAD) and to assess their association with carotid ultrasound findings and other cardiovascular risk factors.Method and resultsWe scanned, using 64-slice multi-detector computed tomography, 57 asymptomatic FDRs (47 ± 9 years old; 44% male, 56% female), out of the 111 FDRs previously phenotyped for cardiovascular (CV) risk factors. The controls were 616 individuals (57 ± 10 years old; 76% male, 24% female) with no family history of cardiovascular disease, chest pain or diabetes selected out of the 3500 subjects scanned between 2002 and 2007. FDRs had higher risk of abnormal CAC scores compared to controls; odds ratio (OR) for the 75th percentile was 1.96 (95% CI 1.04 – 3.67, p < 0.05).ConclusionThe frequency of abnormal CAC scores is two-fold higher in asymptomatic FDRs than in controls. CAC scan provides additional information on CV risk assessment in asymptomatic FDRs, particularly for those in the intermediate risk category.Clinical trial registrationNCT00387595

【 授权许可】

Unknown   
© Taraboanta et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.