Smoking during pregnancy and risk of abnormal glucose tolerance: a prospective cohort study

BMC Pregnancy and Childbirth

Research Article

Amy E Haskins¹  Elena Carbone²  Penelope Pekow³  Lisa Chasan-Taber³  Elizabeth R Bertone-Johnson³  Renée T Fortner³ 

[1] Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME, USA;Division of Biostatistics & Epidemiology, Department of Public Health, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA;Department of Nutrition, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA;Division of Biostatistics & Epidemiology, Department of Public Health, School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA, USA;

关键词: Gestational Diabetes Mellitus;    Early Pregnancy;    Gestational Weight Gain;    Hispanic Woman;    Pregnancy Risk Assessment Monitoring System;   

DOI  :  10.1186/1471-2393-10-55

 received in 2009-12-09, accepted in 2010-09-17,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDisturbances in glucose metabolism during pregnancy are associated with negative sequalae for both mother and infant. The association between smoking and abnormal glucose tolerance (AGT) remains controversial. Therefore, the aim of this study was to examine the relationship between smoking prior to and during pregnancy and risk of AGT.MethodsWe utilized data from a prospective cohort of 1,006 Hispanic (predominantly Puerto Rican) prenatal care patients in Western Massachusetts. Women reported pre- and early pregnancy smoking at recruitment (mean = 15 weeks) and mid pregnancy smoking at a second interview (mean = 28 weeks). AGT was defined as > 135 mg/dL on the routine 1-hour glucose tolerance test (1-hr OGTT). We used multivariable regression to assess the effect of pre, early, and mid-pregnancy smoking on risk of AGT and screening plasma glucose value from the 1-hr OGTT.ResultsIn age-adjusted models, women who smoked > 0-9 cigarettes/day in pre-pregnancy had an increased risk of AGT (OR = 1.90; 95% CI 1.02-3.55) compared to non-smokers; this was attenuated in multivariable models. Smoking in early (OR = 0.48; 95% CI 0.21-1.10) and mid pregnancy (OR = 0.38; 95% CI 0.13-1.11) were not associated with AGT in multivariable models. Smoking during early and mid pregnancy were independently associated with lower glucose screening values, while smoking in pre-pregnancy was not.ConclusionsIn this prospective cohort of Hispanic women, we did not observe an association between smoking prior to or during pregnancy and risk of AGT. Findings from this study, although based on small numbers of cases, extend prior research to the Hispanic population.

【 授权许可】

Unknown   
© Haskins et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.