Three-dimensional substructure measurements for the differential diagnosis of ground glass nodules

BMC Pulmonary Medicine

Research Article

Gang Yu¹  Chengzhong Zhang²  Cuidi Li³  Mingzheng Peng⁴  Jinwu Wang⁵ 

[1] Department of Anesthesiology, Binzhou Central Hospital, Binzhou Medical College, Binzhou, China;Department of Radiology, Shanghai First People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;School of Biomedical Engineering, MED-X Research Institute of Shanghai Jiao Tong University, Shanghai, China;Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School Of Medicine, Room 703, No. 3 Building, 693 Zhizaoju Road, 200011, Shanghai, China;Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School Of Medicine, Room 703, No. 3 Building, 693 Zhizaoju Road, 200011, Shanghai, China;School of Biomedical Engineering, MED-X Research Institute of Shanghai Jiao Tong University, Shanghai, China;

关键词: Peak;    Substructure;    Ground-glass nodule;    Follow-up;    Three-dimensional;    Lung cancer;   

DOI  :  10.1186/s12890-017-0438-y

 received in 2017-02-17, accepted in 2017-06-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe analyzed the differences between maximum and peak computed tomography (CT) numbers (M-P), respectively representing the densities of the solid center and the main periphery of ground-glass nodules (GGNs), and the average change in M-P velocity (V(M-P)) during follow-up to differentiate between pre-invasive (PIA) and invasive adenocarcinoma (IAC).MethodsData of 102 patients were retrospectively collected and analyzed in our study including 43 PIAs and 59 IACs. Diameters, total volumes, and the maximum and peak CT numbers in CT number histograms were measured and followed for at least 3 months. This study was registered retrospectively.ResultsThe M-P values for IACs were higher than those for PIAs (p = 0.001), with an area under the curve (AUC) of 0.810 and a threshold of 489.5 Hounsfield units (HU) in ROC analysis. The V(M-P) values for IACs were smaller than those for PIAs (p = 0.04), with an AUC of 0.805 and a threshold of 11.01 HU/day.ConclusionsM-P and V(M-P) values may help distinguish IACs from PIAs by representing the changes in the sub-structural densities of GGNs during follow-up.

【 授权许可】

CC BY   
© The Author(s). 2017