Awareness of cytomegalovirus and risk factors for susceptibility among pregnant women, in Montreal, Canada

BMC Pregnancy and Childbirth

Research Article

Jean-Baptiste Le Meur¹  Valérie Lamarre²  Fatima Kakkar²  Lena Coic²  Bruce Tapiero²  Sarah Wizman³  Céline Rousseau⁴  Marc Boucher⁵ 

[1] Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Pavillon Ferdinand-Vandry (bureau 4633), 1050 Av de la Medicine, G1V0A6, Québec, QC, Canada;Infectious Disease Division, Department of Paediatrics, CHU Sainte Justine, Université de Montréal, 3175 Ch. de la Cote-Sainte-Catherine (bureau 7412), H3T1C5,, Montréal, QC, Canada;Infectious Disease Division, Department of Paediatrics, CHU Sainte Justine, Université de Montréal, 3175 Ch. de la Cote-Sainte-Catherine (bureau 7412), H3T1C5,, Montréal, QC, Canada;5632 Irving Layton, H4W0A2,, Montréal, QC, Canada;Infectious Disease Division, Department of Paediatrics, CHU Sainte Justine, Université de Montréal, 3175 Ch. de la Cote-Sainte-Catherine (bureau 7412), H3T1C5,, Montréal, QC, Canada;Department of Microbiology, CHU Sainte-Justine, Université de Montréal, 3175 Ch. de la Cote-Sainte-Catherine (bureau 2901), H3T1C5,, Montréal, QC, Canada;Obstetric and Gynecology Department, CHU Sainte Justine, Université de Montréal, 3175 Ch. de la Cote-Sainte-Catherine (bureau 4822), H3T1C5,, Montréal, QC, Canada;

关键词: Cytomegalovirus;    Serostatus;    Awareness;    Socio-demographic risk factors;    Pregnant women;   

DOI  :  10.1186/s12884-016-0844-9

 received in 2015-10-15, accepted in 2016-03-11,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAdvances in diagnostic and therapeutic modalities for congenital cytomegalovirus (CMV) infection have generated a mounting interest in identifying mothers susceptible to CMV. The objectives of this study were to evaluate the prevalence and socio-demographic determinants of CMV susceptibility and CMV awareness, among pregnant women, in Montreal, Quebec.MethodsBetween April and December 2012, women delivering at Centre Hospitalier Universitaire Sainte Justine were recruited for the study. Stored serum from the first trimester of pregnancy was tested for CMV IgG. Knowledge about CMV and socio-demographic characteristics were collected via standardized questionnaire.ResultsFour hundred and ninety one women were enrolled in the study. Overall, 225 mothers (46 %) were seronegative for CMV, and 85 % (n = 415) were unaware of CMV or the associated risks in pregnancy. Significant risk factors for CMV seronegative status included Canadian vs. foreign born (aOR 6.88, 95 % CI 4.33–10.94), and high vs. low family income (aOR 4.68, 95 % CI 2.09–10.48). Maternal employment status was the only significant predictor of CMV unawareness, with unemployed mothers at the highest risk (aOR 85.6, 95 % CI 17.3–421.3).ConclusionsNearly half of pregnant women studied were at risk of primary infection, and yet, the majority was unaware of potential risks associated with CMV. Canadian born mothers and those with a high socioeconomic status were more likely to be CMV seronegative. Increased education about CMV infection, through public health interventions and obstetrician/pediatric counseling, is needed for all pregnant women.

【 授权许可】

CC BY   
© Wizman et al. 2016