Perioperative blood transfusion adversely affects prognosis after resection of lung cancer: a systematic review and a meta-analysis

BMC Surgery

Research Article

Haixing Luan¹  Lupeng Wu²  Feng Ye²  Yanming Zhou²  Jie Jiang³ 

[1] Department of Anesthesiology, First Hospital Affiliated to Xiamen University, 361003, Xiamen, China;Department of Hepatobiliary & Pancreatovascular Surgery, Oncologic Center of Xiamen; First affiliated Hospital of Xiamen University, 361003, Xiamen, China;Department of Thoracic Surgery, First affiliated Hospital of Xiamen University; Oncologic Center of Xiamen, 361003, Xiamen, China;

关键词: Lung cancer;    Blood transfusion;    Survival;    Surgery;    Meta-analysis;   

DOI  :  10.1186/1471-2482-14-34

 received in 2014-03-03, accepted in 2014-05-19,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIt is speculated that blood transfusion may induce adverse consequences after cancer surgery due to immunosuppression. This study was intended to assess the impact of perioperative blood transfusion on the prognosis of patients who underwent lung cancer resection.MethodsEligible studies were identified through a computerized literature search. The pooled relative risk ratio (RR) with 95% confidence interval (CI) was calculated using Review Manager 5.1 Software.ResultsEighteen studies with a total of 5915 participants were included for this meta-analysis. Pooled analysis showed that perioperative blood transfusion was associated with worse overall survival (RR: 1.25, 95% CI: 1.13-1.38; P <0.001) and recurrence-free survival (RR: 1.42, 95% CI: 1.20-1.67; P <0.001) in patients with resected lung cancer.ConclusionsPerioperative blood transfusion appears be associated with a worse prognosis in patients undergoing lung cancer resection. These data highlight the importance of minimizing blood transfusion during surgery.

【 授权许可】

Unknown   
© Luan et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.