LumbSten: The lumbar spinal stenosis outcome study

BMC Musculoskeletal Disorders

Study Protocol

Florian Brunner¹  Alexander Nydegger²  Beat Michel²  Jürg Hodler³  Johann Steurer⁴  Ulrike Held⁴  François Porchet⁵  Anne F Mannion⁵  Kan Min⁶ 

[1] Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Forchstrasse 340, 8008, Zürich, Switzerland;Department of Rheumatology and Institute for Physical Medicine of the University Hospital of Zurich, 8091, Zurich, Switzerland;Division of Diagnostic and Interventional Radiology of the University Hospital of Zurich, 8091, Zurich, Switzerland;Horten Centre for patient oriented research and knowledge transfer, University of Zurich, University Hospital, 8091, Zurich, Switzerland;Spine Surgery Unit, Clinic Schulthess, Lengghalde 2, 8008, Zürich, Switzerland;Spine Surgery Unit, Department of Orthopedics; Balgrist University Hospital, Forchstrasse 340, 8008, Zürich, Switzerland;

关键词: Oswestry Disability Index;    Spinal Stenosis;    Lumbar Spinal Stenosis;    Minimal Clinical Important Difference;    Epidural Injection;   

DOI  :  10.1186/1471-2474-11-254

 received in 2010-10-11, accepted in 2010-11-02,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLumbar spinal stenosis is the most frequent reason for spinal surgery in elderly people. For patients with moderate or severe symptoms different conservative and surgical treatment modalities are recommended, but knowledge about the effectiveness, in particular of the conservative treatments, is scarce. There is some evidence that surgery improves outcome in about two thirds of the patients. The aims of this study are to derive and validate a prognostic prediction aid to estimate the probability of clinically relevant improvement after surgery and to gain more knowledge about the future course of patients treated by conservative treatment modalities.Methods/DesignThis is a prospective, multi-centre cohort study within four hospitals of Zurich, Switzerland. We will enroll patients with neurogenic claudication and lumbar spinal stenosis verified by Computer Tomography or Magnetic Resonance Imaging. Participating in the study will have no influence on treatment modality. Clinical data, including relevant prognostic data, will be collected at baseline and the Swiss Spinal Stenosis Questionnaire will be used to quantify severity of symptoms, physical function characteristics, and patient's satisfaction after treatment (primary outcome). Data on outcome will be collected 6 weeks, and 6, 12, 24 and 36 months after inclusion in the study. Applying multivariable statistical methods, a prediction rule to estimate the course after surgery will be derived.DiscussionThe ultimate goal of the study is to facilitate optimal, knowledge based and individualized treatment recommendations for patients with symptomatic lumbar spinal stenosis.

【 授权许可】

CC BY   
© Steurer et al; licensee BioMed Central Ltd. 2010