QT dispersion in patients with systemic lupus erythematosus: the impact of disease activity

BMC Cardiovascular Disorders

Research Article

Lida Liaghat¹  Gholam reza Rezaian¹  Mohammad Ghahartars¹  Yadollah Mahmoody¹  Javad Kojuri²  Mohammad ali Nazarinia³ 

[1] Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran;Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran;Medical education, Cardiologist, Interventionis,t Cardiology Department, Namazi Hospital, Zand St, Shiraz, Iran;Internal Medicine Department, Rheumatology Group, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: SLE;    Disease activity score;    QT dispersion;   

DOI  :  10.1186/1471-2261-12-11

 received in 2011-10-26, accepted in 2012-02-27,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPatients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogeneity of cardiac repolarization and autonomic function. We compared the increase in QT dispersion in SLE patients with high disease activity and mild or moderate disease activity.Methods and ResultsOne hundred twenty-four patients with SLE were enrolled in the study. Complete history and physical exam, ECG, echocardiography, exercise test and SLE disease activity index (SLEDAI) were recorded. Twenty patients were excluded on the basis of our exclusion criteria. The patients were divided to two groups based on SLEDAI: 54 in the high-score group (SLEDAI > 10) and 50 in the low-score group (SLEDAI < 10).QT dispersion was significantly higher in high-score group (58.31 ± 18.66 vs. 47.90 ± 17.41 respectively; P < 0.004). QT dispersion was not significantly higher in patients who had received hydroxychloroquine (54.17 ± 19.36 vs. 50.82 ± 15.96, P = 0.45) or corticosteroids (53.58 ± 19.16 vs. 50.40 + 11.59, P = 0.47). There was a statistically significant correlation between abnormal echocardiographic findings (abnormalities of pericardial effusion, pericarditis, pulmonary hypertension and Libman-Sacks endocarditis) and SLEADI (P < 0.004).ConclusionsQT dispersion can be a useful, simple noninvasive method for the early detection of cardiac involvement in SLE patients with active disease. Concerning high chance of cardiac involvement, cardiovascular evaluation for every SLE patient with a SLEDAI higher than 10 may be recommended.Trial registrationClinicaltrial.gov registration NCT01031797

【 授权许可】

CC BY   
© Kojuri et al; licensee BioMed Central Ltd. 2012