Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action

BMC Musculoskeletal Disorders

Research Article

Frances MK Williams¹  Tim D Spector¹  Alex J MacGregor²  Ian M Clark³  Rose M Davidson³  Aedin Cassidy⁴  Jane Skinner⁴ 

[1] Dept Twin Research and Genetic Epidemiology, King's College London, London, UK;Dept Twin Research and Genetic Epidemiology, King's College London, London, UK;School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK;School of Biological Sciences, University of East Anglia, Norwich, UK;School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK;

关键词: Dietary Pattern;    Food Frequency Questionnaire;    Twin Pair;    Allicin;    Ajoene;   

DOI  :  10.1186/1471-2474-11-280

 received in 2010-06-16, accepted in 2010-12-08,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundPatterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were further studied in vitro.MethodsCross-sectional study conducted in a large population-based volunteer cohort of twins. Food intake was evaluated using the Food Frequency Questionnaire; OA was determined using plain radiographs. Analyses were adjusted for age, BMI and physical activity. Subsequent in vitro studies examined the effects of allium-derived compounds on the expression of matrix-degrading proteases in SW1353 chondrosarcoma cells.ResultsData were available, depending on phenotype, for 654-1082 of 1086 female twins (median age 58.9 years; range 46-77). Trends in dietary analysis revealed a specific pattern of dietary intake, that high in fruit and vegetables, showed an inverse association with hip OA (p = 0.022). Consumption of 'non-citrus fruit' (p = 0.015) and 'alliums' (p = 0.029) had the strongest protective effect. Alliums contain diallyl disulphide which was shown to abrogate cytokine-induced matrix metalloproteinase expression.ConclusionsStudies of diet are notorious for their confounding by lifestyle effects. While taking account of BMI, the data show an independent effect of a diet high in fruit and vegetables, suggesting it to be protective against radiographic hip OA. Furthermore, diallyl disulphide, a compound found in garlic and other alliums, represses the expression of matrix-degrading proteases in chondrocyte-like cells, providing a potential mechanism of action.

【 授权许可】

CC BY   
© Williams et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.