Imaging-genomics reveals driving pathways of MRI derived volumetric tumor phenotype features in Glioblastoma

BMC Cancer

Research Article

David A. Gutman¹  William D. Dunn¹  Patrick Grossmann²  Hugo J. W. L. Aerts³  Chad A. Holder⁴ 

[1] Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA;Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA;Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA;Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA;Radiology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA;

关键词: Imaging-genomics;    Radiomics;    Glioblastoma;    Volumetric;    Pathways;    Prediction;    Noninvasive;    Radiation Oncology;    Neuro-imaging;   

DOI  :  10.1186/s12885-016-2659-5

 received in 2015-09-28, accepted in 2016-08-01,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundGlioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely unknown. An Imaging-Genomics analysis was performed to reveal the mechanistic associations between MRI derived quantitative volumetric tumor phenotype features and molecular pathways.MethodsOne hundred fourty one patients with presurgery MRI and survival data were included in our analysis. Volumetric features were defined, including the necrotic core (NE), contrast-enhancement (CE), abnormal tumor volume assessed by post-contrast T1w (tumor bulk or TB), tumor-associated edema based on T2-FLAIR (ED), and total tumor volume (TV), as well as ratios of these tumor components. Based on gene expression where available (n = 91), pathway associations were assessed using a preranked gene set enrichment analysis. These results were put into context of molecular subtypes in GBM and prognostication.ResultsVolumetric features were significantly associated with diverse sets of biological processes (FDR < 0.05). While NE and TB were enriched for immune response pathways and apoptosis, CE was associated with signal transduction and protein folding processes. ED was mainly enriched for homeostasis and cell cycling pathways. ED was also the strongest predictor of molecular GBM subtypes (AUC = 0.61). CE was the strongest predictor of overall survival (C-index = 0.6; Noether test, p = 4x10−4).ConclusionGBM volumetric features extracted from MRI are significantly enriched for information about the biological state of a tumor that impacts patient outcomes. Clinical decision-support systems could exploit this information to develop personalized treatment strategies on the basis of noninvasive imaging.

【 授权许可】

CC BY   
© The Author(s). 2016