Non-tunneled versus tunneled dialysis catheters for acute kidney injury requiring renal replacement therapy: a prospective cohort study

BMC Nephrology

Research Article

Dionne A. Graham¹  Ayal A. Aizer²  Megan F. May³  Salena Cui³  Sushrut S. Waikar³  Arnaud D. Kaze³  Margaret E. Chen³  Mallika L. Mendu⁴  Naomi Shin⁵ 

[1] Center for Applied Pediatric Quality Analytics, Boston Children’s Hospital, Boston, MA, USA;Department of Radiation Oncology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Division of Renal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;Division of Renal Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;One Brigham Circle, Brigham and Women’s Hospital, 02115, Boston, MA, USA;Internal Medicine Residency Program, Mount Auburn Hospital, Cambridge, MA, USA;

关键词: Acute kidney injury (AKI);    Renal replacement therapy (RRT);    Non-tunneled dialysis catheter (NTDC);    Tunneled dialysis catheter (TDC);    Continuous venovenous hemofiltration (CVVH);    Intermittent hemodialysis (IHD);   

DOI  :  10.1186/s12882-017-0760-x

 received in 2017-08-16, accepted in 2017-11-16,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAcute kidney injury requiring renal replacement therapy (AKI-RRT) is associated with high morbidity, mortality and resource utilization. The type of vascular access placed for AKI-RRT is an important decision, for which there is a lack of evidence-based guidelines.MethodsWe conducted a prospective cohort study over a 16-month period with 154 patients initiated on AKI-RRT via either a non-tunneled dialysis catheter (NTDC) or a tunneled dialysis catheter (TDC) at an academic hospital. We compared differences in renal replacement delivery and mechanical and infectious outcomes between NTDCs and TDCs.ResultsPatients who received TDCs had significantly better RRT delivery, both with continuous venovenous hemofiltration (CVVH) and intermittent hemodialysis (IHD), compared to patients who received NTDCs; these findings were confirmed after multivariable adjustment for AKI-specific disease severity score, history of chronic kidney disease, renal consult team, and AKI cause. In CVVH and IHD, the median venous and arterial blood flow pressures were significantly higher with TDCs compared to NTDCs (p < 0.001). Additionally for CVVH, the median number of interruptions per catheter was higher with NTDCs compared to TDCs (Rate Ratio (RR) 2.7; p < 0.001), and for IHD, a higher median blood flow was seen with TDCs (p < 0.001). There were a significantly higher number of mechanical complications with NTDCs (RR 13.6 p = 0.001). No significant difference was observed between TDCs and NTDCs for positive blood cultures per catheter.ConclusionsCompared to NTDCs, TDCs for patients with AKI-RRT had improved RRT delivery and fewer mechanical complications. Initial TDC placement for AKI-RRT should be considered when not clinically contraindicated given the potential for improved RRT delivery and outcomes.

【 授权许可】

CC BY   
© The Author(s). 2017