Growth of breast cancer recurrences assessed by consecutive MRI

BMC Cancer

Research Article

David Azria¹  Denis Hoa²  Patrice Taourel²  Emmanuelle Bouic-Pages²  Ingrid Millet² 

[1] CRLC Val d'Aurelle, Montpellier, France;Centre Hospitalier Universitaire Lapeyronie, Montpellier, France;

关键词: Breast Cancer;    Contralateral Breast;    Contralateral Breast Cancer;    Breast Magnetic Resonance Imaging;    Tumour Growth Rate;   

DOI  :  10.1186/1471-2407-11-155

 received in 2010-11-14, accepted in 2011-04-28,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundWomen with a personal history of breast cancer have a high risk of developing an ipsi- or contralateral recurrence. We aimed to compare the growth rate of primary breast cancer and recurrences in women who had undergone prior breast magnetic resonance imaging (MRI).MethodsThree hundred and sixty-two women were diagnosed with breast cancer and had undergone breast MRI at the time of diagnosis in our institution (2005 - 2009). Among them, 37 had at least one prior breast MRI with the lesion being visible but not diagnosed as cancer. A linear regression of tumour volume measured on MRI scans and time data was performed using a generalized logistic model to calculate growth rates. The primary objective was to compare the tumour growth rate of patients with either primary breast cancer (no history of breast cancer) or ipsi- or contralateral recurrences of breast cancer.ResultsTwenty women had no history of breast cancer and 17 patients were diagnosed as recurrences (7 and 10 were ipsi- and contralateral, respectively). The tumour growth rate was higher in contralateral recurrences than in ipsilateral recurrences (growth rate [10-3 days-1] 3.56 vs 1.38, p < .001) or primary cancer (3.56 vs 2.09, p = 0.01). Differences in tumour growth were not significant for other patient-, tumour- or treatment-related characteristics.ConclusionsThese findings suggest that contralateral breast cancer presents accelerated growth compared to ipsilateral recurrences or primary breast events.

【 授权许可】

Unknown   
© Millet et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.