Should oral anticoagulant therapy be continued during dental extraction? A meta-analysis

BMC Oral Health

Research Article

Jinru Li¹  Juan Xu²  Jinglong Liu²  Shuo Yang²  Quan Shi² 

[1] Department of Stomatology, Chinese People’s Liberation Army 322 Hospital, 2 Yunzhong Road, 037000, Datong, China;Department of Stomatology, Chinese People’s Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China;

关键词: Oral anticoagulant therapy;    Dental extraction;    Bleeding;    Meta-analysis;   

DOI  :  10.1186/s12903-016-0278-9

 received in 2016-06-22, accepted in 2016-08-12,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundOral anticoagulation therapy is widely used to reduce the risks of thromboembolism. However, the therapy increases the risk of hemorrhage during the surgical procedures. The aim of this meta-analysis was to evaluate the bleeding risk of patients continuing or discontinuing oral anticoagulant therapy while undergoing dental extractions.MethodsSix electronic databases, including PubMed, Embase, Cochrane library, Web of Science, China Biology Medicine disc (CBM), and China National Knowledge Infrastructure (CNKI), were searched in March, 2016. Relevant articles were screened by two independent reviewers under our inclusion criteria. Quality was evaluated using the Cochrane Collaboration risk of bias tool. Meta-analyses were conducted with fixed and random effects models as appropriate.ResultsSix studies (with a total of 591 patients) were included in our meta-analysis. Our results showed that there was no significant difference in the bleeding risk between patients continuing or discontinuing oral anticoagulant therapy while undergoing dental extractions (risk ratio, 1.31; 95 % CI, 0.79, 2.14; P > 0.05). There was also no significant difference in bleeding risk 1 day (risk ratio, 0.91; 95 % CI, 0.35, 2.37; P > 0.05) and 7 days (risk ratio, 1.47; 95 % CI, 0.83, 2.59; P > 0.05) after the dental extraction.ConclusionUnder current studies and evidence, it appears that patients continuing oral anticoagulant therapy do not have an increased risk of bleeding after dental extractions compared to patients who discontinue oral anticoagulant therapy.

【 授权许可】

CC BY   
© The Author(s). 2016