Effect of lycopene against gastroesophageal reflux disease in experimental animals

BMC Complementary and Alternative Medicine

Research Article

Arvind Kumar Giri¹  Manjari Singh¹  Jitendra Kumar Rawat¹  Swetlana Gautam¹  Gaurav Kaithwas¹ 

[1] Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, 226 025, Lucknow, UP, India;

关键词: Anti-inflammatory;    Dual inhibitors;    Esophagitis;    GERD;    Interleukin-6;    Oxidative stress;    Pantoprazole;   

DOI  :  10.1186/s12906-015-0631-6

 received in 2014-08-16, accepted in 2015-03-23,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundLycopene is a robust antioxidant with significant antiulcer activity. Henceforth, the present study was ventured to elucidate the effect of lycopene on experimental esophagitis.MethodsGroups of rats were subjected to forestomach and pylorus ligation with subsequent treatment with lycopene (50 and 100 mg/kg, po) and pantoprazole (30 mg/kg, po).ResultsTreatment with lycopene evidenced sententious physiological protection when scrutinized for pH, acidity (total and free), volume of gastric juices and esophagitis index. Lycopene further embarked diminishing effect on oxidative stress through synchronising lipid and protein peroxidation along with regulating the enzymatic activity of SOD and catalase. Lycopene also modified the levels of immunoregulatory cytokines (IL- 1β and IL-6) favourably. The dose dependent efficacy of lycopene in the current experimental condition was also attested when exemplified morphologically through scanning electron microscopy.ConclusionFrom the current line of evidences, it was concluded that lycopene can impart momentous protection against experimental esophagitis by wrapping up the reactive oxygen species and through dual inhibition of the arachidonic acid pathway.

【 授权许可】

Unknown   
© Giri et al. 2015. ᅟ