Factors associated with clinical outcome in 25 patients with avian influenza A (H7N9) infection in Guangzhou, China

BMC Infectious Diseases

Research Article

ZhiCong Yang¹  Zongqiu Chen¹  Jianyun Lu¹  Hui Liu¹  Lei Luo¹  Hui Wang¹  Kuibiao Li¹  Ming Wang¹  XinCai Xiao¹ 

[1] Guangzhou Centre for Disease Control and Prevention, No. 1, Qide Rd, Jiahe, Baiyun, 510440, Guangzhou, China;

关键词: Avian influenza;    H7N9 subtype;    Clinical characteristic;   

DOI  :  10.1186/s12879-016-1840-4

 received in 2015-12-07, accepted in 2016-09-16,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundGuangzhou reported its first laboratory-confirmed case of influenza A (H7N9) on January 10, 2014. A total of 25 cases were reported from the first wave of the epidemic until April 8, 2014. The fatality rate was much higher than in previous reports. The objective of the current work was to describe the clinical and epidemiological characteristics of A (H7N9) patients in Guangzhou and explore possible reasons for the high fatality rate.MethodsClinical and epidemiological information regarding A (H7N9) cases in Guangzhou was collected through review of medical records and field research. Data regarding clinical and laboratory features, treatment, and outcomes were extracted.ResultsOf the 25 patients, 84 % (21/25) had one or more underlying diseases. Fifteen patients (60.0 %) developed moderate to severe acute respiratory distress syndrome (ARDS), and 14 (56 %) died of the ARDS or multiorgan failure. Patients with longer delay between onset of illness and initiation of oseltamivir treatment were more likely to develop ARDS. Elevated C-creative protein, aspartate aminotransferase, creatine kinase, and lymphocytopenia predicted a higher risk of developing ARDS.ConclusionsThe presence of underlying diseases and clinical complications predicted poor clinical outcome. Early oseltamivir treatment was associated with a reduced risk of developing ARDS.

【 授权许可】

CC BY   
© The Author(s). 2016