Short term serum pharmacokinetics of diammine silver fluoride after oral application

BMC Oral Health

Research Article

Edgar Chirinos¹  Elsa Vasquez¹  Jorge L Castillo²  Russell Dills³  Peter Milgrom⁴  Donald R Taves⁴  Lloyd L Mancl⁴  Gene E Watson⁵  Graciela Zegarra⁶ 

[1] Area of Pediatric Dentistry, Universidad Catolica Santa Maria de Arequipa, San Jose S/N, Arequipa, Peru;Department of Dentistry for Children and Adolescents, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, 31, Lima, Peru;Department of Environmental Health, University of Washington, 98195-7234, Seattle, WA, USA;Department of Oral Health Sciences, Northwest Center to Reduce Oral Health Disparities, University of Washington, Box 357475, 98195-7475, Seattle, WA, USA;Eastman Institute for Oral Health, University of Rochester, 14642, Rochester, NY, USA;Private practice in Arequipa, Garcilazo de la Vega 102- Umacollo, Arequipa, Peru;

关键词: Acute pain;    Tooth;    Medical device;    Topical agent;    Pharmacology;    Toxicology;   

DOI  :  10.1186/1472-6831-12-60

 received in 2012-06-21, accepted in 2012-12-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThere is growing interest in the use of diammine silver fluoride (DSF) as a topical agent to treat dentin hypersensitivity and dental caries as gauged by increasing published research from many parts of the world. While DSF has been available in various formulations for many years, most of its pharmacokinetic aspects within the therapeutic concentration range have never been fully characterized.MethodsThis preliminary study determined the applied doses (3 teeth treated), maximum serum concentrations, and time to maximum serum concentration for fluoride and silver in 6 adults over 4 h. Fluoride was determined using the indirect diffusion method with a fluoride selective electrode, and silver was determined using inductively coupled plasma-mass spectrometry. The mean amount of DSF solution applied to the 3 teeth was 7.57 mg (6.04 μL).ResultsOver the 4 hour observation period, the mean maximum serum concentrations were 1.86 μmol/L for fluoride and 206 nmol/L for silver. These maximums were reached 3.0 h and 2.5 h for fluoride and silver, respectively.ConclusionsFluoride exposure was below the U.S. Environmental Protection Agency (EPA) oral reference dose. Silver exposure exceeded the EPA oral reference dose for cumulative daily exposure over a lifetime, but for occasional use was well below concentrations associated with toxicity. This preliminary study suggests that serum concentrations of fluoride and silver after topical application of DSF should pose little toxicity risk when used in adults.Clinical trials registrationNCT01664871.

【 授权许可】

Unknown   
© Vasquez et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.