FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells

BMC Cardiovascular Disorders

Research Article

Feng Wang¹  Jin-ying Zhang²  En Li³  Shao-hui Niu⁴  Li-qiang Sun⁴  Li Li⁴  Ting Wang⁵  Tao Wang⁶ 

[1] CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China;Department of Cardiovascular internal medicine, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Cardiovascular internal medicine, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Cardiovascular internal medicine, The second Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Cardiovascular internal medicine, The second Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;Department of Gerontology, Shaanxi People’s Hospital, Xi’an, P. R. China;Department of Gerontology, The second Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China;

关键词: Macrophage;    ER stress;    FGF21;    Foam cell;    CHOP;   

DOI  :  10.1186/s12872-015-0077-2

 received in 2014-10-10, accepted in 2015-07-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundFGF21,as a member of the fibroblast growth factor superfamily, is an important endogenous regulator to systemic glucose and lipid metabolism. Elevated serum FGF21 levels have been reported in subjects with coronary heart disease and carotid artery plaques. The formation and apoptosis of foam cell, induced by ox-LDL and oxysterols, are key steps in the development of atherosclerosis.MethodsIn this study, THP1 derived macrophages were induced into foam cells by ox-LDL or sterols. The formation and apoptosis of foam cells treated with or without FGF21 were analyzed.ResultsWe demonstrated that the accumulation of cholesterol was decreased after FGF21 treatment in THP1 macrophage derived foam cells. Consistently, the apoptosis of macrophage was alleviated dramatically with FGF21 treatment. ERK1/2 knockdown didn’t abrogate the effect of FGF21 on THP1 macrophage derived foam cells. However, FGF21 suppressed the induced expression of CHOP and DR5 in THP1 macrophage derived foam cells.ConclusionFGF21 protects against the formation and apoptosis of THP1 macrophages derived foam cells through suppressing the expression of CHOP.

【 授权许可】

Unknown   
© Li et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.