Elevated serum neutrophil elastase is related to prehypertension and airflow limitation in obese women

BMC Women's Health

Research Article

Amany E Zeidan¹  Elham R Abdel-Samie²  Azza A El-Baiomy²  Amany A Mousa³  Omayma M Saleh³  Mervat M El-Eshmawy³  Eman H El-Adawy³ 

[1] Chest Department, Faculty of Medicine, Mansoura University Hospital, Mansoura University, Mansoura, Egypt;Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;Internal Medicine Department, Specialized Medical Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt;

关键词: Chronic Obstructive Pulmonary Disease;    High Density Lipoprotein Cholesterol;    Force Vital Capacity;    Pulmonary Function Test;    Neutrophil Elastase;   

DOI  :  10.1186/1472-6874-11-1

 received in 2010-04-16, accepted in 2011-01-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundNeutrophil elastase level/activity is elevated in a variety of diseases such as atherosclerosis, systolic hypertension and obstructive pulmonary disease. It is unknown whether obese individuals with prehypertension also have elevated neutrophil elastase, and if so, whether it has a deleterious effect on pulmonary function. Objectives: To determine neutrophil elastase levels in obese prehypertensive women and investigate correlations with pulmonary function tests.MethodsThirty obese prehypertensive women were compared with 30 obese normotensive subjects and 30 healthy controls. The study groups were matched for age. Measurements: The following were determined: body mass index, waist circumference, blood pressure, lipid profile, high sensitivity C-reactive protein, serum neutrophil elastase, and pulmonary function tests including forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.ResultsSerum neutrophil elastase concentration was significantly higher in both prehypertensive (405.8 ± 111.6 ng/ml) and normotensive (336.5 ± 81.5 ng/ml) obese women than in control non-obese women (243.9 ± 23.9 ng/ml); the level was significantly higher in the prehypertensive than the normotensive obese women. FEV1, FVC and FEV1/FVC ratio in both prehypertensive and normotensive obese women were significantly lower than in normal controls, but there was no statistically significant difference between the prehypertensive and normotensive obese women. In prehypertensive obese women, there were significant positive correlations between neutrophil elastase and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low density lipoprotein cholesterol, high sensitivity C-reactive protein and negative correlations with high density lipoprotein cholesterol, FEV1, FVC and FEV1/FVC.ConclusionNeutrophil elastase concentration is elevated in obese prehypertensive women along with an increase in high sensitivity C-reactive protein which may account for dyslipidemia and airflow dysfunction in the present study population.

【 授权许可】

Unknown   
© El-Eshmawy et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.