Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China

BMC Infectious Diseases

Research Article

Hong Zhu¹  G. Bea. A. Wisman²  Wen-feng Wang³  Xiao-lei Guo³  Zheng-yu Zeng³  Shang-wei Wu⁴  Ed Schuuring⁵  Rong Wang⁶ 

[1] Department of Epidemiology & Biostatistics, Tianjin Medical University, Tianjin, China;Department of Gynecologic Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;Department of Microbiology, Kingmed Diagnostics, Guangzhou, China;Department of Microbiology, Kingmed Diagnostics, Guangzhou, China;Division of Clinical Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin, China;Department of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;Division of Clinical Microbiology, School of Laboratory Medicine, Tianjin Medical University, Tianjin, China;Department of Gynecologic Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;

关键词: Human papillomavirus;    hrHPV prevalence;    HPV genotyping;    Cervical cancer;    China;   

DOI  :  10.1186/s12879-015-0998-5

 received in 2014-10-16, accepted in 2015-06-23,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundType-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of hrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical cancer among different populations. To establish a foundation for HPV-based screening and vaccination programs in China, we investigated the most recent HPV prevalence and genotypic distributions in different female age groups and geographical regions in China.MethodsIn 2012, a total of 120,772 liquid-based cytological samples from women enrolled for population- or employee-based cervical screening in 37 Chinese cities were obtained by the Laboratory of Molecular Infectious Diseases of Guangzhou KingMed. A total of 111,131 samples were tested by Hybrid Capture II and the other 9,641 were genotyped using the Tellgenplex™ HPV DNA Assay.ResultsThe total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou) and varied by region. The regions of Nanchang, Changsha, Hangzhou, Chengdu, Fuzhou, Guangdong, and Guiyang could be considered the low prevalence regions. Age-specific prevalence showed a “two-peak” pattern, with the youngest age group (15–19 years) presenting the highest hrHPV infection rate (30.55 %), followed by a second peak for the 50–60-year-old group. Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %), followed by HPV58 (2.74 %). Two genotypes HPV6 (4.01 %) and HPV11 (2.29 %) were predominant in the low-risk HPV (lrHPV) type, while the mixed genotypes HPV16 + 52 and HPV52 + 58 were most common in women with multiple infections.ConclusionsThis study shows that HPV infection in China has increased to the level of an “HPV-heavy-burden” zone in certain regions, with prevalence varying significantly among different ages and regions. Data from this study represent the most current survey of the nationwide prevalence of HPV infection in China, and can serve as valuable reference to guide nationwide cervical cancer screening and HPV vaccination programs.

【 授权许可】

Unknown   
© Wang et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.