Neonatal Hyperbilirubinemia in a Marginalized Population on the Thai-Myanmar Border: a study protocol

BMC Pediatrics

Study Protocol

Julie A. Simpson¹  Claudia Turner²  Patrick van Rheenen³  Michaël Boele van Hensbroek⁴  Borimas Hanboonkunupakarn⁵  Verena I. Carrara⁶  Moo Kho Paw⁶  Margreet Trip-Hoving⁶  Germana Bancone⁷  François Nosten⁷  Rose McGready⁷  Laurence Thielemans⁸ 

[1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom;Cambodia-Oxford Medical Research Unit, Angkor Hospital for Child, Siem Reap, Cambodia;Angkor Hospital for Children, Siem Reap, Cambodia;Department of Pediatric Gastroenterology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;Global Child Health Group, Emma Children’s Hospital/Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands;Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Rd, Bangkok, Thailand;Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom;Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand;Department of Paediatrics, Université Libre de Bruxelles, Faculty of Medicine, Brussels, Belgium;

关键词: Neonatal hyperbilirubinemia;    Jaundice;    Phototherapy;    Infant;    Low-resource;    Refugee;    Migrant;    Resource-limited setting;    G6PD deficiency;    Neurodevelopment;   

DOI  :  10.1186/s12887-017-0798-8

 received in 2016-04-27, accepted in 2017-01-18,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThis study aims to identify risk factors and the neurodevelopmental impact of neonatal hyperbilirubinemia in a limited-resource setting among a refugee and migrant population residing along the Thai-Myanmar border, an area with a high prevalence of glucose-6-phosphate dehydrogenase-deficiency.MethodsThis is an analytic, observational, prospective birth cohort study including all infants of estimated gestational age equal to or greater than 28 weeks from mothers who followed antenatal care in the Shoklo Malaria Research Unit clinics. At birth, a series of clinical exams and laboratory investigations on cord blood will be carried out. Serum bilirubin will be measured in all infants during their first week of life. All the infants of the cohort will be clinically followed until the age of one year, including monitoring of their neurodevelopment.DiscussionThe strength of this study is the prospective cohort design. It will allow us to collect information about the pregnancy and detect all infants with neonatal hyperbilirubinemia, to observe their clinical response under treatment and to compare their neurodevelopment with infants who did not develop neonatal hyperbilirubinemia. Our study design has some limitations in particular the generalizability of our findings will be limited to infants born after the gestational age of 28 weeks onwards and neurodevelopment to the end of the first year of life.Trial registrationClinicalTrials.gov ID NCT02361788, registration date September 1st, 2014.

【 授权许可】

CC BY   
© The Author(s). 2017