Chemical composition, anthelmintic, antibacterial and antioxidant effects of Thymus bovei essential oil

BMC Complementary and Alternative Medicine

Research Article

Shadi K’aibni¹  Lina Adwan²  Abdel Naser Zaid³  Naser Shraim³  Nidal Jaradat³ 

[1] Center of Birzeit University Testing Laboratories, Birzeit University, P.O. Box 14, Birzeit, State of Palestine;College of Pharmacy Nursing and Health Professions, Birzeit University, P.O. Box 14, Birzeit, State of Palestine;Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus, State of Palestine;

关键词: Thymus bovei;    Essential oil;    Antioxidant;    Anthelmintic;    Antimicrobial;   

DOI  :  10.1186/s12906-016-1408-2

 received in 2016-06-11, accepted in 2016-10-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundIt has been recently recognized that oxidative stress, helminth and microbial infections are the cause of much illness found in the underdeveloped, developing and developed countries. The present study was undertaken to identify the chemical composition, and to assess anthelmintic, antimicrobial and antioxidant effects of Thymus bovei essential oil.MethodsThe chemical composition of the essential oil was analyzed using gas chromatography mass spectrometry (GC-MS). Antimicrobial activity was tested against the selected strains from American Type Culture Collection (ATCC) and clinical isolates such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Methicillin Resistant Staphylococcus aureus, Candida albicans using MIC assay. The anthelmintic assay was carried out on adult earthworm (Pheretima posthuma), while antioxidant activity was analyzed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method.ResultsTrans-geraniol (35.38 %), α-citral (20.37 %) and β-citral (14.76 %) were the major compounds comprising 70.51 % of the essential oil. Our results showed that T. bovei essential oil exhibited strong anthelmintic activity, even higher than piperazine citrate, the used reference standard, with potential antioxidant activity almost equal to the Trolox standard. Furthermore, T. bovei essential oil had powerful antibacterial and antifungal activities against the studied pathogens.ConclusionEssential oil of T. bovei exerted excellent antioxidant, antimicrobial, and anthelmintic activities. Moreover, this study found that T. bovei volatile oil contains active substances that could potentially be used as natural preservatives in food and pharmaceutical industries, these substances could also be employed for developing new anthelmintic, antimicrobial and antioxidant agents.

【 授权许可】

CC BY   
© The Author(s). 2016