The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients

BMC Endocrine Disorders

Research Article

Chenxiao Liu¹  Ying Zhang¹  Ying Wang¹  Qian Li¹  Xiu Feng¹  Jian Zhu¹  Qi Li¹  Xianjin Ke² 

[1] Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Qinhuai District, 210006, Nanjing, Jiangsu Province, China;Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, China;

关键词: Netrin-1;    Mechanism;    Insulin resistance;    Inflammation;    Type 2 diabetes mellitus;   

DOI  :  10.1186/s12902-016-0112-z

 received in 2015-12-03, accepted in 2016-05-24,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPancreatic β-cell dysfunction resulting from inflammation has been recognized to contribute to type 2 diabetes mellitus (T2DM). Netrin-1 is a new indicator of subclinical inflammation and it has a role in β-cell apoptosis. This study evaluated the level of netrin-1 in newly diagnosed T2DM patients and explored whether netrin-1 is a reliable marker or a key factor in the development of T2DM.MethodsNetrin-1 level was determined using a commercially available human enzyme-linked immune sorbent assay (ELISA) kit. The homeostasis model assessment of insulin resistance (HOMA-IR) was used as an index to measure insulin resistance. The sample consisted of 30 patients with newly diagnosed T2DM who had a glycosylated hemoglobin (HbA1c) level ranging from 7.5 % (58 mmol/mol) to 10.5 % (91 mmol/mol). The control group consisted of 26 healthy individuals matched for age and body mass index.ResultsThe netrin-1 level of T2DM patients was significantly lower than that of healthy controls (p < 0.01). Logistic regression analysis showed that the level of netrin-1 was negatively correlated with HOMA-IR, fasting blood glucose, postprandial blood glucose, fasting insulin and HbA1c.ConclusionsPlasma netrin-1 levels were decreased in patients with newly diagnosed T2DM, and the levels of netrin-1 were negatively associated with IR and glucose homeostasis. Future studies on the precise mechanism will offer new insights into the prevention and treatment of T2DM.

【 授权许可】

CC BY   
© The Author(s). 2016