Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer

BMC Cancer

Case Report

Gerhard Moser¹  Alexander Schlattau²  Gerda Ricken³  Romana Höftberger³  Daniel Neureiter⁴  Wolfgang Tränkenschuh⁴  Florian Huemer⁵  Clemens Hufnagl⁵  Alexander Egle⁵  Lukas Weiss⁵  Thomas Melchardt⁵  Teresa Magnes⁵  Richard Greil⁵ 

[1] Department of Otorhinolaryngology, Paracelsus Medical University Salzburg, Salzburg, Austria;Department of Radiology, Paracelsus Medical University Salzburg, Salzburg, Austria;Institute of Neurology, Medical University of Vienna, Vienna, Austria;Institute of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria;Third Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute with Laboratory of Immunological and Molecular Cancer Research and Center for Clinical Cancer and Immunology Trials, Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, 5020, Salzburg, Austria;

关键词: Anti-Hu antibody;    Cerebellar ataxia;    Paraneoplastic syndrome;    Head & neck;    Spindle cell carcinoma;   

DOI  :  10.1186/s12885-015-2020-4

 received in 2015-02-12, accepted in 2015-12-15,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundParaneoplastic syndromes are most frequently associated with small cell lung carcinoma, hematologic and gynecologic malignancies while reports in head and neck cancer are rare.Case presentationWe present the case of a 60-year old female patient who developed paraneoplastic cerebellar degeneration upon locoregional recurrence of a poorly differentiated spindle cell carcinoma of the nasal cavity and paranasal sinus. The neurological symptoms, especially ataxia, stabilized after resection of tumor recurrence and concomitant chemoradiotherapy whereas anti-Hu-antibodies remained positive. Despite the unfavorable prognosis of paraneoplastic neurological disorders associated with onconeural antibodies, the patient achieved long-standing stabilization of neurological symptoms.ConclusionWe report the first patient with anti-Hu antibodies and paraneoplastic cerebellar degeneration associated with a spindle cell carcinoma of the head and neck. We recommend that evaluation of neurological symptoms in patients with this tumor entity should also include paraneoplastic syndromes as differential diagnoses and suggest early extensive screening for onconeural antibodies.

【 授权许可】

CC BY   
© Huemer et al. 2015