Genome-wide expression patterns in physiological cardiac hypertrophy

BMC Genomics

Research Article

Sophia Tsoka¹  Christos A Ouzounis²  Ajay M Shah³  Ignat Drozdov⁴ 

[1] Centre for Bioinformatics, School of Physical Sciences & Engineering - King's College London (KCL) - Strand, WC2R 2LS, London, UK;Centre for Bioinformatics, School of Physical Sciences & Engineering - King's College London (KCL) - Strand, WC2R 2LS, London, UK;Computational Genomics Unit, Institute of Agrobiotechnology - Centre for Research & Technology Hellas, PO Box 361, GR-57001, Thessaloniki, Greece;King's College London (KCL) BHF Centre of Research Excellence - Cardiovascular Division, School of Medicine - James Black Centre, 125 Coldharbour Lane, SE5 9NU, London, UK;King's College London (KCL) BHF Centre of Research Excellence - Cardiovascular Division, School of Medicine - James Black Centre, 125 Coldharbour Lane, SE5 9NU, London, UK;Centre for Bioinformatics, School of Physical Sciences & Engineering - King's College London (KCL) - Strand, WC2R 2LS, London, UK;

关键词: Left Ventricular Hypertrophy;    Node Degree;    Betweenness Centrality;    KEGG Pathway;    Core Network;   

DOI  :  10.1186/1471-2164-11-557

 received in 2010-06-06, accepted in 2010-10-11,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundPhysiological left ventricular hypertrophy (LVH) involves complex cardiac remodeling that occurs as an adaptive response to chronic exercise. A stark clinical contrast exists between physiological LVH and pathological cardiac remodeling in response to diseases such as hypertension, but little is known about the precise molecular mechanisms driving physiological adaptation.ResultsIn this study, the first large-scale analysis of publicly available genome-wide expression data of several in vivo murine models of physiological LVH was carried out using network analysis. On evaluating 3 million gene co-expression patterns across 141 relevant microarray experiments, it was found that physiological adaptation is an evolutionarily conserved processes involving preservation of the function of cytochrome c oxidase, induction of autophagy compatible with cell survival, and coordinated regulation of angiogenesis.ConclusionThis analysis not only identifies known biological pathways involved in physiological LVH, but also offers novel insights into the molecular basis of this phenotype by identifying key networks of co-expressed genes, as well as their topological and functional properties, using relevant high-quality microarray experiments and network inference.

【 授权许可】

Unknown   
© Drozdov et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.