The prevalence of drug resistance among treatment-naïve HIV-1-infected individuals in China during pre- and post- 2004

BMC Infectious Diseases

Research Article

Yang Han¹  Taisheng Li¹  Hongbin Song²  Wenfu Zhang²  Shuai Chang³  Daomin Zhuang⁴  Hanping Li⁴  Siyang Liu⁴  Yongjian Liu⁴  Jingyun Li⁴  Zuoyi Bao⁴  Lin Li⁴ 

[1] Department of Infectious Disease, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, 100730, Beijing, Dongcheng district, China;Institute of Disease Control and Prevention, Academy of Military Medical Science, 100071, Beijing, China;Institute of Disease Control and Prevention, Academy of Military Medical Science, 100071, Beijing, China;Department of Clinical Laboratory, PLA Army General Hospital, 100700, Beijing, China;State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Science, No. 20 East Street, 100071, Beijing, Fengtai district, China;

关键词: HIV;    Prevalence;    Treatment-naïve;    Transmitted drug resistance;    Antiretroviral therapy;   

DOI  :  10.1186/s12879-016-1928-x

 received in 2015-12-02, accepted in 2016-10-13,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic.MethodsWe conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database.ResultsOf 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend in the prevalence of overall TDR was observed (p > 0.05).ConclusionsWe identified an intermediate prevalence of transmitted drug resistance (TDR), exhibiting a stable time trend. These findings enhance our understanding of HIV-1 drug resistance prevalence and time trend, and provide some guidelines for the comprehensive public health strategy of TDR prevention.

【 授权许可】

CC BY   
© The Author(s). 2016