High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection

BMC Gastroenterology

Research Article

Zuojiong Gong¹  Deqiang Ma²  Changzheng Ke²  Yue Chen²  Yinhua Zhang²  Jian Kang²  Ping Liu³  Zhongji Meng⁴  Jie Luo⁵  Zhiqiang Wei⁶  Yonghong Zhang⁷ 

[1] Department of Infectious Diseases, Renmin Hospital of Wuhan University, Zhangzhidong Road. 99, 430060, Wuhan, China;Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Department of Infectious Diseases, Renmin Hospital of Wuhan University, Zhangzhidong Road. 99, 430060, Wuhan, China;Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Department of Neurology, Taihe Hospital, Hubei University of Medicine, South Renmin Road. 32, 442000, Shiyan, Hubei, China;Institute of Biomedicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Institute of Wudang Chinese Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, China;

关键词: Resistin;    Proinflammatory cytokines;    Hepatitis B;    Liver cirrhosis;    Liver failure;   

DOI  :  10.1186/s12876-016-0558-5

 received in 2016-06-10, accepted in 2016-12-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundStudies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possible marker role of resistin in the inflammatory process of chronic hepatitis B.MethodsIn this study, 234 subjects with HBV infection were retrospectively selected, including 85 patients with chronic hepatitis B (CHB), 70 patients with HBV-related liver cirrhosis (LC-B), and 79 patients with HBV-related liver failure (LF-B). Serum levels of resistin, IL-1, IL-6, IL-17, IL-23, TNF-α, and TGF-β1 were assayed by ELISA. Demographic and clinical characteristics of patients were extracted from clinical databases of Taihe Hospital, Hubei University of Medicine, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), and liver stiffness (LS).ResultsAll the selected patients with HBV infection showed significantly increased levels of serum resistin, which was rarely detectable in the healthy controls. Serum resistin levels in patients with CHB, LC-B, and LF-B were 4.119 ± 5.848 ng/mL, 6.370 ± 6.834 ng/mL, and 6.512 ± 6.076 ng/mL, respectively. Compared with the CHB group, patients with LC-B or LF-B presented with significantly higher serum levels of resistin (p < 0.01). On the other hand, all of the enrolled patients had high serum levels of IL-1, IL-6, IL-17, TNF-α, and TGF-β1, but not IL-23. Interestingly, serum levels of resistin was significantly positively correlated with serum levels of TGF-β1 in LC-B patients (R = 0.3090, p = 0.0290), with IL-17 in LC-B (R = 0.4022, p = 0.0038) and LF-B patients (R = 0.5466, p < 0.0001), and with AST (R = 0.4501, p = 0.0036) and LS (R = 0.3415, p = 0.0310) in CHB patients.ConclusionsHigh serum resistin associates with intrahepatic inflammation and necrosis and may be used as an index of disease severity for patients with chronic HBV infection.

【 授权许可】

CC BY   
© The Author(s). 2017