BMC Musculoskeletal Disorders | |
Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing Rheumatoid Arthritis: a cross-sectional study | |
Research Article | |
Helena Forsblad-d'Elia1  Hans Carlsten1  | |
[1] Sahlgrenska Academy at University of Gothenburg, Department of Rheumatology and Inflammation Research, Centre for Bone and Arthritis Research, Box 480, S-405 30, Gothenburg, Sweden; | |
关键词: Rheumatoid Arthritis; Bone Mineral Density; Early Rheumatoid Arthritis; Disease Modify Anti Rheumatic Drug; Established Rheumatoid Arthritis; | |
DOI : 10.1186/1471-2474-12-242 | |
received in 2011-04-19, accepted in 2011-10-24, 发布年份 2011 | |
来源: Springer | |
【 摘 要 】
BackgroundThe aims were to explore bone mineral density (BMD) by digital X-ray radiogrammetry (DXR) in postmenopausal women with long-lasting rheumatoid arthritis (RA) in relation to dual x-ray absorptiometry (DXA)-BMD, joint destruction by conventional radiographs and disease related variables in a cross-sectional study.MethodsSeventy-five postmenopausal women with RA were examined by DXA measuring DXA-BMD of the forearm, total hip and lumbar spine, by scoring joint destruction on plain radiographs by the method of Larsen and by DXR-BMD in metacarpals two to four. The DXR-BMD results of the RA women were compared with an age and sex-matched reference database. A function of DXR-BMD in relation to age and disease duration was created. Associations were investigated by bivariate and multiple linear regression analyses.ResultsDXR-BMD was strongly decreased in RA patients compared to the reference database (p < 0.001). Calculations showed that DXR-BMD was not markedly influenced the first years after diagnosis of RA, but between approximately 5-10 years of disease there was a steep decline in DXR-BMD which subsequently levelled off. In multiple regression analyses disease duration, CRP and DXR-BMD were independent variables associated with Larsen score (R2= 0.64). Larsen score and BMD forearm were independent determinants of DXR-BMD (R2 = 0.79).ConclusionsDXR-BMD was strongly reduced and associated with both Larsen score and DXA-BMD forearm in these postmenopausal women with RA implying that DXR-BMD is a technique that reflects both the erosive process and bone loss adjacent to affected joints.
【 授权许可】
CC BY
© Forsblad-d'Elia and Carlsten; licensee BioMed Central Ltd. 2011
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202311098546135ZK.pdf | 428KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]