Quantitative evaluation of hard exudates in diabetic macular edema after short-term intravitreal triamcinolone, dexamethasone implant or bevacizumab injections

BMC Ophthalmology

Research Article

Heeyoon Cho¹  Min Ho Kang¹  Yong Un Shin¹  Han Woong Lim¹  Mincheol Seong¹  Eun Hee Hong¹ 

[1] Department of Ophthalmology, Hanyang University College of Medicine, Seoul, South Korea;

关键词: Bevacizumab;    Dexamethasone implant;    Diabetic macular edema;    Hard exudate;    Triamcinolone;   

DOI  :  10.1186/s12886-017-0578-0

 received in 2016-08-26, accepted in 2017-09-25,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo quantitatively compare short-term hard exudates (HEs) alteration in patients with diabetic macular edema (DME) after intravitreal triamcinolone, dexamethasone implant or bevacizumab injections.MethodsThis retrospective study enrolled DME eyes with HEs that underwent a single-dose intravitreal injection of triamcinolone (25 eyes), dexamethasone implant (20 eyes), or three monthly injections of bevacizumab (25 eyes) and completed at least three months of follow-up. All patients were examined before and after 1, 2 and 3 months of injections. Using color fundus photographs, the amount of HEs was quantified by two masked graders. The difference in HEs area between baseline and each follow-up visit was compared among the three groups.ResultsAfter three months, HEs area was reduced to 52.9 ± 4.21% (P < 0.001) in the triamcinolone group, 63.6 ± 6.08% (P = 0.002) in the dexamethasone implant group, and 85.2 ± 5.07% (P = 0.198) in the bevacizumab group. A significant reduction in HEs appeared at one month in the triamcinolone group (53.5 ± 4.91%, P < 0.001) and at two months in the dexamethasone implant group (70.1 ± 5.21%, P = 0.039).ConclusionsOur study suggests intravitreal steroids (triamcinolone, dexamethasone implants) significantly reduce HEs in DME patients on short-term follow-up, whereas intravitreal bevacizumab does not. Therefore, intravitreal steroids may be useful in DME with HEs in the fovea.

【 授权许可】

CC BY   
© The Author(s). 2017