Early cytological diagnosis of extranodal stage I, primary thyroid Non-Hodgkin lymphoma in elderly patients. Report of two cases and review of the literature

BMC Surgery

Research Article

Elena Vigliar¹  Mario Vitale²  Pio Zeppa²  Alfredo Garzi²  Vincenzo Di Crescenzo²  Alessia Caleo² 

[1] Department of Biomorphological and Functional Sciences, Faculty of Medicine and Surgery, University of Naples "Federico II", Italy;Department of Medicine and Surgery, University of Salerno, Italy;

关键词: Thyroid Nodule;    Cytological Diagnosis;    Hashimoto Thyroiditis;    Thyroid Follicular Cell;    Thyroid Lymphoma;   

DOI  :  10.1186/1471-2482-13-S2-S49

来源: Springer

【 摘 要 】

BackgroundPrimary thyroid lymphomas (PTLs) account for 5% of thyroid malignant tumors and often develop in patients with Hashimoto Thyroiditis (HT). Fine-needle cytology (FNC) is widely used in the diagnosis of thyroid nodules, including those arising in HT. Two PTL cases in HT elderly patients are here described and discussed.MethodsFNC was performed in rapidly enlarged thyroid nodules of 2 elderly patients under ultrasound (US) control. FNC was used to prepare conventional cytologic smears, immunocytochemistry (ICC) and flow cytometry (FC) assessment of cell populations.ResultsThe above cases were diagnosed as well differentiated, small B-cell and diffuse large B-cell thyroid lymphomas, respectively, by means of FNC. The histological diagnoses were mucosa-associated non Hodgkin lymphoma (MALT) and diffuse large B-cell lymphoma (DLBCL), confirming FNC diagnoses, and patients were treated accordingly.ConclusionsFNC diagnosis of PTL is reliable and accurate; it may be conveniently used in the clinical practice since it provides indications for appropriate therapeutic procedures or diagnostic surgery, and avoids to treat benign nodules.

【 授权许可】

Unknown   
© Vigliar et al; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.